Epigenetic mechanisms regulating fate specification of neural stem cells
Epigenetic mechanisms regulating fate specification of neural stem cells
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DOI：
10.1098/rstb.2008.2262
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发表时间：
2008-06-27
影响因子：
6.3
通讯作者：
Nakashima, Kinichi
中科院分区：
文献类型：
--
作者：
Namihira, Masakazu;Kohyama, Jun;Nakashima, Kinichi
神经干细胞具有自我更新和沿着神经元和神经胶质细胞分化的能力。这些过程由细胞外信号（包括细胞因子信号传导）和细胞内程序（如表观遗传修饰）之间的动态相互作用定义。越来越多的证据表明，表观遗传机制，包括，例如，DNA甲基化，组蛋白修饰和非编码RNA表达的变化与神经干细胞的命运特化密切相关。这些表观遗传学改变可以提供协调的系统，在神经细胞分化的每一步调控基因表达。本文综述了表观遗传学在哺乳动物中枢神经系统神经命运特化中的作用。
Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular programmes such as epigenetic modification. There is increasing evidence that epigenetic mechanisms involving, for example, changes in DNA methylation, histone modification and non-coding RNA expression are closely associated with fate specification of NSCs. These epigenetic alterations could provide coordinated systems for regulating gene expression at each step of neural cell differentiation. Here we review the roles of epigenetics in neural fate specification in the mammalian central nervous system.