Psychiatric and behavioral side effects of anti-epileptic drugs in adolescents and children with epilepsy
Psychiatric and behavioral side effects of anti-epileptic drugs in adolescents and children with epilepsy
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DOI：
10.1016/j.ejpn.2017.02.003
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发表时间：
2017-05-01
影响因子：
3.1
通讯作者：
Farooque, P.
中科院分区：
文献类型：
--
作者：
Chen, B.;Detyniecki, K.;Farooque, P.
目的：本研究的目的是比较老年和新型抗癫痫药物（aed）在儿童和青少年癫痫患者中的精神和行为副作用（PBSE）。方法：采用logistic回归分析，检验83个与非aed /患者相关的潜在预测变量与PBSE发生率的相关性。然后，在控制非AED预测因素的情况下，我们比较了每种AED的pbse发生率和导致不耐受（IPBSE）的pbse发生率。结果：922例(
Purpose: The objective of the study was to compare the psychiatric and behavioral side effect (PBSE) profiles of both older and newer antiepileptic drugs (AEDs) in children and adolescent patients with epilepsy.Method: We used logistic regression analysis to test the correlation between 83 non-AED/ patient related potential predictor variables and the rate of PBSE. We then compared for each AED the rate of PBSEs and the rate of PBSEs that led to intolerability (IPBSE) while controlling for non-AED predictors of PBSEs.Results: 922 patients (