Heparan sulfate proteoglycans: a sugar code for vertebrate development?
Heparan sulfate proteoglycans: a sugar code for vertebrate development?
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DOI：
10.1242/dev.098178
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发表时间：
2015-10-15
期刊：
影响因子：
--
通讯作者：
Yost HJ
中科院分区：
文献类型：
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作者：
Poulain FE;Yost HJ
长期以来，在体外和体内的无脊椎动物模型中，硫酸乙酰肝素蛋白多糖(HSPGs)参与了广泛的细胞-细胞信号和细胞-基质相互作用。虽然许多编码HSPG核心蛋白的基因以及产生和修改HSPG糖链的生物合成酶还没有在脊椎动物中进行遗传学分析，但最近的研究表明，HSPG确实在脊椎动物早期发育中调节了广泛的功能，例如在左右构型以及心血管和神经发育过程中。在这里，我们全面概述了HSPGs在这些系统中的各种作用，并探索了具有指导意义的硫酸乙酰肝素糖码的概念，以调节脊椎动物的发育。摘要：这篇综述文章考察了硫酸乙酰肝素蛋白多糖在脊椎动物发育中的作用，并探索了调节发育的指导性‘糖码’的概念。
Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG sugar chains have not yet been analyzed by genetics in vertebrates, recent studies have shown that HSPGs do indeed mediate a wide range of functions in early vertebrate development, for example during left-right patterning and in cardiovascular and neural development. Here, we provide a comprehensive overview of the various roles of HSPGs in these systems and explore the concept of an instructive heparan sulfate sugar code for modulating vertebrate development. Summary: This Review article examines the role of heparan sulfate proteoglycans in vertebrate development and explores the concept of an instructive 'sugar code' for modulating development.