Increased risk for COVID-19 in patients with vitamin D deficiency.
Increased risk for COVID-19 in patients with vitamin D deficiency.
复制标题
DOI：
10.1016/j.nut.2020.111106
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Xue W
中科院分区：
文献类型：
--
作者：
Katz J;Yue S;Xue W
The 2019 coronavirus disease (COVID-19) pandemic has disproportionally affected a variety of patients with underlying risk factors such as respiratory and cardiovascular diseases, diabetes, obesity, and black race. Vitamin D deficiency, which can result in a compromised immune response, has been also linked to increased risk and increased morbidities associated with COVID-19. In the absence of large-scale longitudinal studies to determine the strength of association between vitamin deficiency and COVID-19, cross-sectional studies of large patient cohorts can be used. We used the i2b2 patient's registry platform at the University of Florida Health Center to generate a count of patients using the international classification of diseases (ICD)-10 diagnosis codes for the period of October 1, 2015, through June 30, 2020. Logistic regression of the aggregates was used for the analysis. Patients with vitamin D deficiency were 4.6 times more likely to be positive for COVID-19 (indicated by the ICD-10 diagnostic code COVID19) than patients with no deficiency (P < 0.001). The association decreased slightly after adjusting for sex (odds ratio [OR] = 4.58; P < 0.001) and malabsorption (OR = 4.46; P < 0.001), respectively. The association decreased significantly but remained robust (P < 0.001) after adjusting for race (OR = 3.76; P < 0.001), periodontal disease status (OR = 3.64; P < 0.001), diabetes (OR = 3.28; P < 0.001), and obesity (OR = 2.27; P < 0.001), respectively. In addition, patients with vitamin D deficiency were 5 times more likely to be infected with COVID-19 than patients with no deficiency after adjusting for age groups (OR = 5.155; P < 0.001). Vitamin D deficiency is significantly associated with increased risk for COVID-19.
登录
查看更多内容
影响因子：
3.4
作者：
Lansiaux, Edouard;Pebay, Philippe P.;Forget, Joachim
通讯作者：
Forget, Joachim
影响因子：
13.8
作者：
Meltzer, David O.;Best, Thomas J.;Solway, Julian
通讯作者：
Solway, Julian
影响因子：
9.8
作者：
Asyary, Al;Veruswati, Meita
通讯作者：
Veruswati, Meita
DOI：
10.1136/bmj.i6583
发表时间：
2017-02-15
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Martineau AR;Jolliffe DA;Hooper RL;Greenberg L;Aloia JF;Bergman P;Dubnov-Raz G;Esposito S;Ganmaa D;Ginde AA;Goodall EC;Grant CC;Griffiths CJ;Janssens W;Laaksi I;Manaseki-Holland S;Mauger D;Murdoch DR;Neale R;Rees JR;Simpson S Jr;Stelmach I;Kumar GT;Urashima M;Camargo CA Jr
通讯作者：
Camargo CA Jr
影响因子：
5.4
作者：
Sabbah, Wael;Tsakos, Georgios;Watt, Richard G.
通讯作者：
Watt, Richard G.