Effect of L. acidophilus and B. lactis on blood glucose in women with gestational diabetes mellitus: a randomized placebo-controlled trial
Effect of L. acidophilus and B. lactis on blood glucose in women with gestational diabetes mellitus: a randomized placebo-controlled trial
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DOI：
10.1186/s13098-019-0471-5
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发表时间：
2019-08-28
影响因子：
4.8
通讯作者：
Khalili, Leila
中科院分区：
文献类型：
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作者：
Ebrahimi, Farnaz Sahhaf;Rad, Aziz Homayouni;Khalili, Leila
背景妊娠期糖尿病(GDM)是一种妊娠并发症，可与新生儿并发症和不良妊娠结局相关。最近，有人建议使用益生菌来更好地控制妊娠期糖尿病患者的血糖。本研究的目的是评价益生菌酸奶与普通酸奶对妊娠期糖尿病妇女的疗效。方法采用双盲、安慰剂对照的临床试验，将84例妊娠期糖尿病孕妇随机分为两组，每组42例，每天口服益生菌酸奶300g或安慰剂，疗程8周。干预后比较两组患者血糖、糖化血红蛋白及妊娠结局。结果根据本试验结果，两组患者的一般特征差异无统计学意义(p>；0.05)。益生菌组的空腹和餐后血糖以及糖化血红蛋白水平均显著降低(p<；0.05)，尽管这些变化在安慰剂组中没有统计学意义。干预2个月后，组间比较差异有统计学意义(P<；0.05)。与对照组相比，益生菌组母亲出生的新生儿体重显著降低，巨大儿出生数量明显减少(p<；0.05)。然而，在其他结果值上没有观察到差异。结论与安慰剂相比，服用益生菌酸奶能更好地控制妊娠合并妊娠期糖尿病患者的血糖。该方案还可降低巨大儿的发生率。
Background Gestational diabetes mellitus (GDM) is a complication of pregnancy that can be associated with neonatal complications and adverse pregnancy outcomes. Recently, probiotic use has been proposed for better control of glucose in GDM patients. The aim of this study was to evaluate the effect of probiotic yoghurt compare with ordinary yoghurt on GDM women. Methods In this double-blind placebo-controlled clinical trial, 84 pregnant women with GDM were randomly assigned into two groups of 42 recipients who underwent 300 g/day of probiotic yoghurt or placebo for 8 weeks. Blood glucose, HbA1c, and the outcome of pregnancy were compared between the two groups after the intervention. Results According to the findings of present trial no significant differences were observed in general characteristics between the two groups (p > 0.05). Both fasting and post prandial blood glucose as well as the level of HbA1c were decreased significantly in probiotic group (p < 0.05), although these changes are not statistically significant in the placebo group. The between group differences was significant after the 2 month intervention (p < 0.05). Neonates born of probiotic group mothers, have significantly lower weight and fewer macrosome neonates were born in this group compared with control group (p < 0.05). However, no difference was observed in other values of outcome. Conclusions Our study revealed that better control of blood glucose can be achieved by consumption of probiotic yoghurt in patients whose pregnancy is complicated by GDM, compared with placebo. Also incidence of macrosomia may be decreased by this regimen.