LncRNA ELF3-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma.
LncRNA ELF3-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma.
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DOI：
10.1155/2021/8323487
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发表时间：
2021
影响因子：
2.7
通讯作者：
Pan Y
中科院分区：
文献类型：
--
作者：
Chen T;Zhu C;Wang X;Pan Y
ELF 3反义RNA 1（ELF 3-AS 1）在某些肿瘤中表达，但其在肝细胞癌（HCC）中的作用尚不清楚。本研究旨在通过数据库、生物信息学和统计学分析探讨ELF 3-AS 1与肝癌的关系。 本研究采用Kruskal-Wallis检验、Wilcoxon符号秩检验、Logistic回归、Kaplan-Meier方法、考克斯回归分析、基因集富集分析（GSEA）和免疫浸润分析等方法，探讨ELF 3-AS 1表达与HCC患者临床特征、预后的关系，以及ELF 3-AS 1在HCC中的可能作用。 ELF 3-AS 1在HCC中的高表达与T分期（P < 0.001）、性别（P = 0.006）、肿瘤残留（P = 0.008）、组织学分级（P < 0.001）、癌旁组织炎症（P = 0.011）、AFP（P < 0.001）和血管侵犯（P = 0.028）有关。ELF 3-AS 1高表达与总生存期（OS）（P = 0.001）和DSS（P = 0.047）相关。ELF 3-AS 1表达与HCC患者的OS独立相关（P = 0.011）。在ELF 3-AS 1高表达组中，GPCR-放射性配体结合、M期、A/1类（视紫红质样受体）、细胞周期检查点、翻译、有丝分裂中期和后期、robo受体信号传导、角化和rRNA加工通过GESA差异富集。ELF 3-AS 1表达与免疫浸润细胞有关。 ELF 3-AS 1表达与HCC预后不良相关。ELF 3-AS 1表达与免疫浸润显著相关。ELF 3-AS 1是一种很有前途的生物标志物，可用于HCC的诊断和预后。
Expression of long noncoding RNA (lncRNA) ELF3 antisense RNA 1 (ELF3-AS1) is observed in some cancers, while its role in hepatocellular carcinoma (HCC) is unclear. The study aimed to investigate the relationship between ELF3-AS1 and HCC based on database, bioinformatics, and statistical analysis. In this study, Kruskal–Wallis test, Wilcoxon sign-rank test, logistic regression, Kaplan–Meier method, Cox regression analysis, gene set enrichment analysis (GSEA), and immunoinfiltration analysis were used to assess the relationship between ELF3-AS1 expression and clinical characteristics of HCC patients, the relationship between ELF3-AS1 expression and prognosis of HCC patients, and the possible functions of ELF3-AS1 in HCC. High expression of ELF3-AS1 in patients with HCC was related to T stage (P < 0.001), gender (P = 0.006), residual tumor (P = 0.008), histologic grade (P < 0.001), adjacent hepatic tissue inflammation (P = 0.011), AFP (P < 0.001), and vascular invasion (P = 0.028). High ELF3-AS1 expression was associated with poor overall survival (OS) (P = 0.001) and DSS (P = 0.047). ELF3-AS1 expression (P = 0.011) was independently correlated with OS in HCC patients. In the high ELF3-AS1 expression group, GPCR-radioligand binding, M phase, Class A/1 (rhodopsin-like receptors), cell cycle checkpoints, translation, mitotic metaphase and anaphase, signaling by robo receptors, keratinization, and rRNA processing were differentially enriched by GESA. ELF3-AS1 expression was associated with immune infiltrating cells. ELF3-AS1 expression was associated with poor prognosis in HCC. ELF3-AS1 expression was significantly associated with immune infiltration. ELF3-AS1 is a promising biomarker that can be used for the diagnosis and prognosis of HCC.
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影响因子：
64.5
作者：
Liu J;Lichtenberg T;Hoadley KA;Poisson LM;Lazar AJ;Cherniack AD;Kovatich AJ;Benz CC;Levine DA;Lee AV;Omberg L;Wolf DM;Shriver CD;Thorsson V;Cancer Genome Atlas Research Network;Hu H
通讯作者：
Hu H
影响因子：
3.4
作者：
Zhang, Zhe;Nong, Li;Cheng, Wen-Wu
通讯作者：
Cheng, Wen-Wu
lncRNA ZNF385D-AS2低表达及其在肝癌中的预后意义
影响因子：
4.2
作者：
Zhang, Ze;Wang, Shouqian;Chen, Fangfang
通讯作者：
Chen, Fangfang
影响因子：
2.1
作者：
Jiao, Yan;Li, Yanqing;Liu, Yahui
通讯作者：
Liu, Yahui
影响因子：
4
作者：
Du, Junkai;Chen, Mingyue;Jiao, Xiaoqin
通讯作者：
Jiao, Xiaoqin