A Comparison of Tracer Kinetic Models for T1-Weighted Dynamic Contrast-Enhanced MRI: Application in Carcinoma of the Cervix
A Comparison of Tracer Kinetic Models for T1-Weighted Dynamic Contrast-Enhanced MRI: Application in Carcinoma of the Cervix
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DOI：
10.1002/mrm.22217
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发表时间：
2010-03-01
影响因子：
3.3
通讯作者：
Buckley, David L.
中科院分区：
文献类型：
--
作者：
Donaldson, Stephanie B.;West, Catharine M. L.;Buckley, David L.
Tofts示踪动力学模型常用于分析动态对比增强MRI数据。它们是从一般的双室交换模型（2CXM）推导出来的，但假设等离子体平均传输时间可以忽略不计。2CXM估计组织血浆灌注和毛细血管通透性表面积；Tofts模型估计的传递常数K-trans反映了这两个参数的组合。本研究的目的是比较2CXM和Tofts模型，并报告宫颈癌患者的微血管参数。30例患者采用动态对比增强MRI方案进行扫描预处理，扫描时间为3秒，总扫描时间为4分钟。用两种模型估计全肿瘤参数。2CXM对所有患者的数据都提供了优越的拟合（所有30个P值均< 0.005），并且获得了显著不同的参数估计（P < 0.01）。K-trans（平均值= 0.35 +/- 0.26 min(-1)）不等于组织血浆灌注的绝对值（平均值= 0.65 +/- 0.56 mL/mL/min）或通透性表面积（平均值= 0.14 +/- 0.09 mL/mL/min），但与组织血浆灌注有很强的相关性（r = 0.944; P = 0.01）。用2CXM计算的平均等离子体平均过境时间为22±16秒，这表明等离子体平均过境时间可以忽略不计的假设不适合该数据集，2CXM比Tofts模型更适合其分析。结果表明，在动态增强MRI中选择合适的示踪剂动力学模型的重要性。中华医学杂志(3):691- 697,2010。(C) 2010 Wiley-Liss, Inc。
The Tofts tracer kinetic models are often used to analyze dynamic contrast-enhanced MRI data. They are derived from a general two-compartment exchange model (2CXM) but assume negligible plasma mean transit time. The 2CXM estimates tissue plasma perfusion and capillary permeability-surface area; the Tofts models estimate the transfer constant K-trans which reflects a combination of these two parameters. The aims of this study were to compare the 2CXM and Tofts models and report microvascular parameters in patients with cervical cancer. Thirty patients were scanned pretreatment using a dynamic contrast-enhanced MRI protocol with a 3 sec temporal resolution and a total scan duration of 4 min. Whole-tumor parameters were estimated with both models. The 2CXM provided superior fits to the data for all patients (all 30 P values < 0.005), and significantly different parameter estimates were obtained (P < 0.01). K-trans (mean = 0.35 +/- 0.26 min(-1)) did not equal absolute values of tissue plasma perfusion (mean = 0.65 +/- 0.56 mL/mL/min) or permeability-surface area (mean = 0.14 +/- 0.09 mL/mL/min) but correlated strongly with tissue plasma perfusion (r = 0.944; P = 0.01). Average plasma mean transit time, calculated with the 2CXM, was 22 +/- 16 sec, suggesting the assumption of negligible plasma mean transit time is not appropriate in this dataset and the 2CXM is better suited for its analysis than the Tofts models. The results demonstrate the importance of selecting an appropriate tracer kinetic model in dynamic contrast-enhanced MRI. Magn Reson Med 63:691-700, 2010. (C) 2010 Wiley-Liss, Inc.