A bio‐synthetic hybrid hydrogel formed under physiological conditions consisting of mucin and a synthetic polymer carrying boronic acid
A bio‐synthetic hybrid hydrogel formed under physiological conditions consisting of mucin and a synthetic polymer carrying boronic acid
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在生理条件下形成的生物合成混合水凝胶，由粘蛋白和携带硼酸的合成聚合物组成
DOI：
10.1002/mabi.202200055
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发表时间：
2022
影响因子：
4.6
通讯作者：
Sakai Shinji
中科院分区：
文献类型：
--
作者：
Nakahata Masaki;Tominaga Naoki;Saito Keishi;Nishiyama Keita;Tanino Yuya;Saiki Kiyoshiro;Kojima Masaru;Sakai Shinji
含粘蛋白的生物合成杂化水凝胶在生理条件下通过混合天然粘蛋白和携带硼酸的合成聚合物的水溶液而成功形成。水凝胶在生理溶液中的机械性能和稳定性，例如，细胞培养基是可调的，这取决于聚合物的硼酸含量。溶解在生理溶液中的水凝胶释放天然粘蛋白和含硼酸的聚合物，其可以控制哺乳动物细胞与表面的粘附。
Mucin‐containing bio‐synthetic hybrid hydrogel is successfully formed under physiological conditions upon mixing aqueous solutions of native mucin and synthetic polymers carrying boronic acids. The mechanical properties and stability of the hydrogel in physiological solutions, e.g., cell culture media, are tunable depending on the boronic acid content of polymers. The hydrogel dissolved in the physiological solutions releases native mucin and boronic acid‐containing polymer, which can control the adhesion of mammalian cells to the surface.