Hypertriglyceridemic waist -: A marker of the atherogenic metabolic triad (hyperinsulinemia;: hyperapolipoprotein B;: small, dense LDL) in men?
Hypertriglyceridemic waist -: A marker of the atherogenic metabolic triad (hyperinsulinemia;: hyperapolipoprotein B;: small, dense LDL) in men?
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DOI：
10.1161/01.cir.102.2.179
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发表时间：
2000-07-11
期刊：
影响因子：
37.8
通讯作者：
Després, JP
中科院分区：
文献类型：
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作者：
Lemieux, I;Pascot, A;Després, JP
背景-本研究验证了这样一个假设，即简单的变量，如腰围和空腹血浆甘油三酯(TC)浓度，可以作为筛选工具来识别具有非传统危险因素(胰岛素和载脂蛋白B升高以及小而密集的低密度脂蛋白颗粒)的代谢三联体的男性。方法和结果-对185名健康男性进行的代谢研究(研究1)的结果表明，腰围大于或等于90厘米且甘油三酯水平升高(大于或等于2.0 mmol/L)的男性中有很大比例(>；80%)具有致动脉粥样硬化的代谢三联体的特征。在一项血管造影术研究(研究2)中，对287名患有和不患有冠心病(CAD)的男性样本进行了验证，结果显示只有腰围和甘油三酯水平同时升高的男性患冠心病的风险增加(优势比3.6，P
Background-The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TC) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles).Methods and Results-Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values greater than or equal to 90 cm and with elevated TG levels (greater than or equal to 2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P