Feasibility and Acceptability of Home-Collected Samples for Human Immunodeficiency Virus Preexposure Prophylaxis and Severe Acute Respiratory Syndrome Coronavirus 2 Laboratory Tests in San Francisco Primary Care Clinics.
Feasibility and Acceptability of Home-Collected Samples for Human Immunodeficiency Virus Preexposure Prophylaxis and Severe Acute Respiratory Syndrome Coronavirus 2 Laboratory Tests in San Francisco Primary Care Clinics.
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DOI：
10.1093/ofid/ofab657
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发表时间：
2022-03
影响因子：
4.2
通讯作者：
Liu A
中科院分区：
文献类型：
--
作者：
Saberi P;Ming K;Shrestha I;Scott H;Thorson B;Liu A
由于在大流行就地庇护令期间难以进行实验室检测，本研究的目的是研究进行家庭采集样本进行暴露前预防（PrEP）和严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）实验室检测的可行性和可接受性。我们在旧金山弗朗西斯科初级保健诊所的PrEP患者中进行了一项试点研究。接受PrEP治疗的个体根据需要提供家庭采集的实验室样本，使用干血斑进行第四代人类免疫缺陷病毒抗原/抗体检测、血清肌酐、梅毒抗体和丙型肝炎抗体检测; 3个部位（口咽、直肠和尿液）拭子进行性传播感染检测;鼻咽拭子进行SARS-CoV-2聚合酶链反应检测。我们使用预先确定的基准来确定收集这些实验室样本的可行性和可接受性。在92名同意参加的人中，73人（79.3%）邮寄回了他们的家庭收集试剂盒。近87.7%的人表示，他们对无需进入诊所即可完成实验室检查的能力非常满意。大约49.3%的参与者选择这种家庭收集方法作为他们提供实验室样本的首选。从受试者采集样本到收到检测结果的平均时间从研究第一季度（17天）缩短至研究最后一季度（5天）。我们报告了高水平的可行性和可接受性与使用家庭收集的实验室样本的患者PrEP. Our结果表明，家庭收集的实验室样本的患者PrEP是一个可行的选择，应提供作为一种替代临床收集的实验室样本。在家中采集样本进行艾滋病毒暴露前预防和严重急性呼吸系统综合征冠状病毒2型实验室检测是非常可行和可接受的。这些采集方法是PrEP患者临床采集样本的适当替代方法。
Due to the difficulty of conducting laboratory testing during the pandemic shelter-in-place orders, the objective of this study was to examine the feasibility and acceptability of conducting home-collected samples for preexposure prophylaxis (PrEP) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) laboratory tests. We conducted a pilot study among patients on PrEP in San Francisco primary care clinics. Individuals on PrEP provided home-collected laboratory samples using dried blood spot for fourth-generation human immunodeficiency virus antigen/antibody test, serum creatinine, syphilis antibody, and hepatitis C antibody, as needed; 3-site (oropharyngeal, rectal, and urine) swabbing for sexually transmitted infections; and nasopharyngeal swabbing for SARS-CoV-2 polymerase chain reaction. We examined feasibility and acceptability of collecting these laboratory samples using predefined benchmarks to determine feasibility or acceptability. Of 92 individuals who consented to participate, 73 (79.3%) mailed back their home-collected kit. Nearly 87.7% noted being extremely to moderately satisfied with the ability to complete the laboratory tests without having to come into a clinic. Approximately 49.3% of participants chose this home-collection method as their first choice for providing laboratory samples. Mean time from collection of samples by the participant to receipt of test results was reduced from the first quarter of the study (17 days) to the last quarter of the study (5 days). We report high levels of feasibility and acceptability with the use of home-collected laboratory samples for patients on PrEP. Our results indicate that home-collected laboratory samples for patients on PrEP is a viable option that should be offered as an alternative to clinic-collected laboratory samples. Home-collected samples for HIV preexposure prophylaxis (PrEP) and severe acute respiratory syndrome coronavirus 2 laboratory tests are highly feasible and acceptable. These collection methods are appropriate alternatives to clinic-collected samples for patients on PrEP.
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影响因子：
15.8
作者：
Baeten JM;Heffron R;Kidoguchi L;Mugo NR;Katabira E;Bukusi EA;Asiimwe S;Haberer JE;Morton J;Ngure K;Bulya N;Odoyo J;Tindimwebwa E;Hendrix C;Marzinke MA;Ware NC;Wyatt MA;Morrison S;Haugen H;Mujugira A;Donnell D;Celum C;Partners Demonstration Project Team
通讯作者：
Partners Demonstration Project Team
DOI：
10.1097/qai.0000000000001179
发表时间：
2017-01-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Hosek SG;Rudy B;Landovitz R;Kapogiannis B;Siberry G;Rutledge B;Liu N;Brothers J;Mulligan K;Zimet G;Lally M;Mayer KH;Anderson P;Kiser J;Rooney JF;Wilson CM;Adolescent Trials Network (ATN) for HIVAIDS Interventions
通讯作者：
Adolescent Trials Network (ATN) for HIVAIDS Interventions
DOI：
10.1016/j.bjid.2020.11.002
发表时间：
2021-01
期刊：
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
影响因子：
--
作者：
Hoagland B;Torres TS;Bezerra DRB;Benedetti M;Pimenta C;Veloso VG;Grinsztejn B
通讯作者：
Grinsztejn B
DOI：
10.1007/s13178-015-0212-y
发表时间：
2016-03-01
期刊：
Sexuality research & social policy : journal of NSRC : SR & SP
影响因子：
--
作者：
Grov C;Cain D;Whitfield TH;Rendina HJ;Pawson M;Ventuneac A;Parsons JT
通讯作者：
Parsons JT
影响因子：
3.7
作者：
Stephenson R;Walsh AR;Chavanduka TMD;Sallabank G;Horvath KJ;Castel AD;Bonar EE;Hightow-Weidman L;Bauermeister JA;Sullivan PS
通讯作者：
Sullivan PS