Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy
Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy
复制标题
中空介孔纳米反应器内限制纳米粒子的生长，用于高效 MRI 引导的光动力治疗
DOI：
10.1016/j.cej.2019.122251
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发表时间：
2020-01-01
影响因子：
15.1
通讯作者：
Chen, Hangrong
中科院分区：
文献类型：
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作者：
Du, Wenxian;Liu, Tianzhi;Chen, Hangrong
介孔二氧化硅纳米颗粒(MSN)由于具有良好的结构和可调谐的功能，在生物医学领域具有广泛的应用前景。基于表面活性剂三甲氧基十八烷基硅烷(C18TMS)在不同溶剂中会呈现不同的开关状态，首次提出了一种在MSNS中定点共负载MnOx和Ce6的智能开关策略。多功能医用纳米平台Ce6/MnOx@HMSNS-PEG(CMHP)对肿瘤微环境(TME)中过表达的过氧化氢(H_2O_2)和弱酸性pH具有灵敏的纵向弛豫信号。此外，在TME中，MnOx组分可以与H_2O_2反应生成O-2，与Ce6结合后，可以缓解肿瘤缺氧，进而加速单线态氧(O-1(2))的生成。体外和体内实验结果均证实，所构建的纳米系统可用于MRI引导下的光动力疗法(PDT)，且副作用较小。
Mesoporous silica nanoparticles (MSNs) have been extensively applied as a promising carrier in biomedical application due to their excellent structure with tunable function. Based on the fact that the surfactant trimethoxyoctadecylsilane (C18TMS) could present different on/off states in different solvents, herein, an intelligent "on/off" switching strategy of site-specific co-loading MnOx and Ce6 into MSNs was proposed for the first time. The multifunctional theranostic nanoplatform, i.e., Ce6/MnOx@HMSNs-PEG (CMHP), shows a sensitive longitudinal relaxation signal to the over-expressed hydrogen peroxide (H2O2) and weak acidic pH in the tumor microenvironment (TME). Furthermore, MnOx component could react with H2O2 in TME to generate O-2, which enable to relieve tumorous hypoxia and afterwards accelerate the generation of singlet oxygen (O-1(2) ) upon laser irradiation when combined with Ce6. Both in vitro and in vivo results confirm that this constructed nanosystem can be applied to MRI-guided sufficient photodynamic therapy (PDT) with reduced side-effects.