Nano/microfluidic device for high-throughput passive trapping of nanoparticles.
Nano/microfluidic device for high-throughput passive trapping of nanoparticles.
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DOI：
10.1063/5.0176323
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发表时间：
2023-11
期刊：
影响因子：
3.2
通讯作者：
Tanner Wells;Holger Schmidt;Aaron Hawkins
中科院分区：
文献类型：
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作者：
Tanner Wells;Holger Schmidt;Aaron Hawkins
我们提出了一种设计和制造方法，用于快速收集流体中的纳米颗粒的装置。该设计使用纳米流体通道作为基于尺寸的被动屏障陷阱，以隔离通道中中心点附近的颗粒，该通道也被薄膜覆盖。进入收集区的颗粒在距离中心点6-12 μm半径内被100%效率捕获。对于所测试的压力和几何形状，无颗粒流体的流速范围为1.88至3.69 nl/s。颗粒捕获测试表明，高捕获颗粒计数显著影响流速。对于稀释至30-300 aM（20-200个颗粒/μl）的悬浮液，在500 s内捕获8-80个颗粒。
We present a design and a fabrication method for devices designed for rapid collection of nanoparticles in a fluid. The design uses nanofluidic channels as a passive size-based barrier trap to isolate particles near a central point in the channel, which is also covered by a thin membrane. Particles that enter the collection region are trapped with 100% efficiency within a 6-12 μm radius from a central point. Flow rates for particle-free fluid range from 1.88 to 3.69 nl/s for the pressure and geometries tested. Particle trapping tests show that high trapped particle counts significantly impact flow rates. For suspensions as dilute as 30-300 aM (20-200 particles/μl), 8-80 particles are captured within 500 s.