Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats
Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats
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DOI：
10.2319/112017-801.1
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发表时间：
2018-07-01
影响因子：
3.4
通讯作者：
Yoshida, Noriaki
中科院分区：
文献类型：
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作者：
Ino-Kondo, Airi;Hotokezaka, Hitoshi;Yoshida, Noriaki
目的：为探讨氯化锂（LiCl）对正畸牙齿移动（OTM）、正畸诱导的牙根吸收（OIRR）和骨形态计量学的影响，将10周龄雌性Sprague道利大鼠（n = 32）按每日每千克体重给予LiCl的浓度分为4组：0（对照组）、0.32、0.64和1.28 mM/kg体重。上颌左第一磨牙由10 cN的螺旋弹簧近中移动14天。拍摄微型计算机断层扫描、扫描电子显微镜和扫描激光显微镜图像来测量OTM的量、OIRR的体积和骨形态测量。结果：OIRR明显下降，具体取决于给予的LiCI的量，尽管OTM适度下降。在对照组和0.32 mM组中，牙齿向近中倾斜，根尖向远中移动。另一方面，牙齿倾斜角变小，根尖近中移动0.64和1.28 mM组。在骨形态计量学中，由于给予LiCl，皮质骨矿物质含量和骨体积增加，而松质骨测量值降低。OIRR呈负相关的皮质骨测量，和量的OTM显着相关的皮质骨morphometry.Conclusions：在大鼠中，氯化锂降低OIRR，诱导近中移动的牙根尖。OIRR与皮质骨形态计量学呈正相关。
Objective: To investigate the influence of lithium chloride (LiCI) on orthodontic tooth movement (OTM), orthodontically induced root resorption (OIRR), and bone morphometry.Materials and Methods: Ten-week-old female Sprague Dawley rats (n = 32) were divided into four groups based on the concentration of LiCI administered daily per kilogram body weight: 0 (control group), 0.32, 0.64, and 1.28 mM/kg body weight. The maxillary left first molars were moved mesially by a 10 cN coil spring for 14 days. Micro-computed tomography, scanning electron microscope, and scanning laser microscope images were taken to measure the amount of OTM, the volume of OIRR, and bone morphometry.Results: OIRR clearly decreased depending on the amount of LiCI administered, although OTM moderately decreased. The tooth inclined mesially and the root apex moved distally in the control and 0.32 mM groups. On the other hand, the tooth inclination angle became smaller and the root apex moved mesially in the 0.64 and 1.28 mM groups. In bone morphometry, the cortical bone mineral content and bone volume increased because of LiCI administration, and the trabecular bone measurements decreased. OIRR negatively correlated to the cortical bone measurements, and the amount of OTM significantly correlated to the cortical bone morphometry.Conclusions: In rats, LiCI reduced OIRR, which induced mesial movement of the tooth root apex. OIRR positively correlated to cortical bone morphometry.