Sex-Specific Association between Serum Vitamin D Status an Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population
Sex-Specific Association between Serum Vitamin D Status an Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population
复制标题
血清维生素 D 状态与血脂谱之间的性别特异性关联：中国中老年人群的横断面研究
DOI：
10.3177/jnsv.66.105
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发表时间：
2020-01-01
影响因子：
1.6
通讯作者：
Wang, Le
中科院分区：
文献类型：
--
作者：
Huang, Fei;Liu, Qingquan;Wang, Le
研究表明，维生素D状态可能与血脂异常有关，但结果相互矛盾，可能存在性别差异。本研究的目的是探讨中国中老年人维生素D状况与血脂和血浆致动脉粥样硬化指数（AIP，动脉粥样硬化的预测因子）之间的性别特异性关联。研究对象为来自某健康管理中心的4，021名中老年人。根据25（OH）D的含量将个体分为三分位。线性和逻辑回归模型被用来估计维生素D水平和血脂之间的三分之一之间的关联。所有参与者的平均血清25（OH）D水平为21.60（16.60 - 27.20）ng/mL。校正潜在混杂因素后，所有受试者中25（OH）D升高10 ng/mL与甘油三酯（TG）降低1.156 mmol/L和AIP降低0.068 mmol/L以及高密度脂蛋白胆固醇（HDL-C）升高0.051 mmol/L相关。此外，25（OH）D缺乏与高胆固醇血症的患病率增加有关（比值比（OR），1.880; 95%置信区间（CI），1.351 - 2.615），低脂蛋白血症/HDL（OR，1.505; 95%CI，1.146 - 1.977）和AIP异常（OR，1.933; 95%CI，1.474 - 2.534），25（OH）D缺乏的女性患低脂蛋白血症/HDL的风险是25（OH）D水平充足的女性的2.02倍（95%CI，1.044 - 3.904;所有p值
Studies have shown that vitamin D status might be associated with dyslipidaemia, but results are conflicting and there might exist sex differences. The aim of our study was to explore the sex-specific association between vitamin D status and scrum lipids and atherogenic index of plasma (AIP, a predictor for atherosclerosis) among Chinese middle-aged and elderly adults. A total of 4,021 middle-aged and elderly participants from a health management centre were included in this cross-sectional study. The individuals were classified into tertiles according to scrum 25(OH)D. Linear and logistic regression models were used to estimate the association between vitamin D levels and serum lipids among the tertiles. The mean serum 25(OH)D level was 21.60 (16.60-27.20) ng/mL in all participants. After adjusting for potential confounders, a 10 ng/mL increase in 25(OH)D was associated with decreases of 1.156 mmol/L in triglycerides (TGs) and 0.068 in the AIP and an increase of 0.051 mmol/L in high-density lipoprotein cholesterol (HDL-C) in all subjects. In addition, 25(OH)D deficiency was associated with an increased prevalence of hypertriglyceridaemia (odds ratio (OR), 1.880; 95% confidence interval (CI), 1.351-2.615), hypoalphalipoproteinaemia/HDL (OR, 1.505; 95% CI, 1.146-1.977) and abnormal AIP (OR, 1.933; 95% CI, 1.474-2.534) in males, and 25(OH)D-deficient women had a 2.02-fold higher risk for hypoalphalipoproteinaemia/HDL than women with sufficient 25(OH)D levels (95% CI, 1.044-3.904; all p values