Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score
Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score
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DOI：
10.1177/0267659114558287
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发表时间：
2015-09-01
期刊：
影响因子：
1.2
通讯作者：
Cayli, M.
中科院分区：
文献类型：
--
作者：
Borekci, A.;Gur, M.;Cayli, M.
背景资料：与没有侧支供应的患者相比，冠状动脉侧支循环（CCC）发育良好的患者的长期心脏死亡率降低。心血管风险标志物，如N-末端脑钠肽前体高敏C反应蛋白（hs-CRP）和高敏心肌肌钙蛋白T（hs-cTnT）是心血管死亡率的独立预测因子。目的：本研究的主要目的是探讨CCC与心血管危险标志物之间的关系。我们前瞻性地纳入了427例慢性完全闭塞的稳定性冠状动脉疾病患者（平均年龄：57.5 ± 11.1岁）。根据Rentrop评分将患者分为两组：（a）CCC发育不良组（Rentrop 0和1）和（B）CCC发育良好组（Rentrop 2和3）。同时检测NT-proBNP、hs-CRP、hs-cTnT、尿酸等生化指标。结果：CCC发育不良组糖尿病、高血压发生率明显高于CCC发育不良组（P
Background: Compared to patients without a collateral supply, long-term cardiac mortality is reduced in patients with well-developed coronary collateral circulation (CCC). Cardiovascular risk markers, such as N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitive C-reactive protein (hs-CRP) and high-sensitive cardiac troponin T (hs-cTnT) are independent predictors for cardiovascular mortality.Objectives: The main goal of this study was to examine the relationship between CCC and cardiovascular risk markers.Methods: We prospectively enrolled 427 stable coronary artery disease patients with chronic total occlusion (mean age: 57.511.1 years). The patients were divided into two groups, according to their Rentrop scores: (a) poorly developed CCC group (Rentrop 0 and 1) and (b) well-developed CCC group (Rentrop 2 and 3). NT-proBNP, hs-CRP, hs-cTnT, uric acid and other biochemical markers were also measured. The SYNTAX score was calculated for all patients.Results: The patients in the poorly developed CCC group had higher frequencies of diabetes and hypertension (p