A case-control study on liver cancer with special emphasis on the possible aetiological role of schistosomiasis.
A case-control study on liver cancer with special emphasis on the possible aetiological role of schistosomiasis.
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肝癌病例对照研究，特别强调血吸虫病可能的病因学作用。
DOI：
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发表时间：
1984
影响因子：
7.7
通讯作者：
S. Yamamoto
中科院分区：
文献类型：
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作者：
Y. Inaba;Imobuhiro Maruchi;M. Matsuda;N. Yoshihara;S. Yamamoto
为了阐明肝癌与可疑病因因素之间的关系，在山梨县的七家医院进行了病例对照研究，那里的肝癌死亡率明显高于相应的全国数字。该县也被认为是日本血吸虫病流行区之一。在两年的研究期间，选择了62例肝癌病例和相同数量的对照。进行了日本血吸虫皮试、乙肝病毒血清学检测和问卷调查。配对分析结果表明，乙肝表面抗原（HBsAg）、血吸虫病史和饮酒与肝癌的发生有显著相关性，其OR值分别为10.0、9.5和3.2。这三个因素的人群归因危险度分别为21.3%、71.8%和39.8%。以上结果提示，HBsAg和血吸虫病史均为肝癌的重要危险因素，血吸虫病可能比乙肝病毒更重要。这三个因素的组合分析表明，每个因素可能与肝癌的乘法，而不是相加。
In order to elucidate the relationship between liver cancer and suspected aetiological factors, a case-control study was carried out at seven hospitals in Yamanashi prefecture, where the mortality rate of the disease was significantly higher than the corresponding national figure. This prefecture was also recognised as one of the endemic areas for Schistosoma japonicum in Japan. Sixty-two cases of liver cancer, and the same number of controls were selected during the two-year study period. A skin test for Schistosoma japonicum, serum tests for HB virus and a questionnaire study were carried out. The results of matched pair analysis revealed that liver cancer was significantly highly correlated with three factors, that is, HBs antigen (HBsAg), history of schistosomiasis, and daily intake of alcohol, and that their odds ratios were 10.0, 9.5 and 3.2 respectively. The values of percentage population attributable risk for these three factors were estimated to be 21.3%, 71.8% and 39.8% respectively. The above findings suggest that HBsAg and history of schistosomiasis are both important risk factors for liver cancer and that schistosomiasis may be much more important than HB virus in the area. The analysis of combinations of these three factors suggest that each factor might be related to liver cancer multiplicatively rather than additively.