Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis.
Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis.
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DOI：
10.1097/ypg.0000000000000018
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发表时间：
2014-04
影响因子：
0.9
通讯作者：
Prescott CA
中科院分区：
文献类型：
--
作者：
Lee LO;Prescott CA
本研究的主要目的是：(i)通过荟萃分析检验COMT val158met多态性与焦虑相关性状的基因型关联；（ii）检验性别和种族作为该关联的调节因子，以及（iii）评估该关联是否因特定焦虑特征而不同。从PubMed或PsycInfo数据库、会议摘要和listserv帖子中确定了COMT val18met多态性与焦虑特征的关联研究。排除标准为：(a)儿科样本，(b)完全临床样本，(c)选择非焦虑表型的样本。对基因型之间焦虑的标准化平均差异进行汇总，得出所有可用样本以及按性别和种族分层的亚组（高加索人与亚洲人）的平均效应值。建构特异性分析用于评估COMT与神经质、伤害回避和行为抑制的关系。27项符合条件的研究（N=15,979）纳入了现有资料。总体研究结果显示了性别特异性和种族特异性效应：在高加索男性的研究中，Val纯合子比Met纯合子具有更高的神经质（95%CI: 0.02 - 0.25, p = 0.03），在亚洲男性的研究中，Val纯合子具有更高的伤害规避（95%CI: 0.14 - 0.72, p = 0.004）。在女性中没有发现明显的关联，当研究跨越种族或焦虑特征时，效应值会减小。结论：本荟萃分析为COMT val158met多态性与焦虑特征之间的性别和种族差异提供了证据。我们的发现有助于目前对前额叶多巴胺能传递与焦虑之间关系的了解。
The main goals of this study were: (i) to examine genotypic association of the COMT val158met polymorphism with anxiety-related traits via a meta-analysis; (ii) to examine sex and ethnicity as moderators of the association, and (iii) to evaluate whether the association differed by particular anxiety traits. Association studies of the COMT val18met polymorphism and anxiety traits were identified from the PubMed or PsycInfo databases, conference abstracts and listserv postings. Exclusion criteria were: (a) pediatric samples, (b) exclusively clinical samples, and (c) samples selected for a non-anxiety phenotype. Standardized mean differences in anxiety between genotypes were aggregated to produce mean effect sizes across all available samples, and for subgroups stratified by sex and ethnicity (Caucasians vs. Asians). Construct-specific analysis was conducted to evaluate the association of COMT with neuroticism, harm avoidance, and behavioral inhibition. Twenty seven eligible studies (N=15,979) with available data were identified. Overall findings indicate sex-specific and ethnic-specific effects: Val homozygotes had higher neuroticism than Met homozygotes in studies of Caucasian males ( , 95%CI: 0.02 – 0.25, p = 0.03), and higher harm avoidance in studies of Asian males ( , 95%CI: 0.14 – 0.72, p = 0.004). No significant associations were found in women and effect sizes were diminished when studies were aggregated across ethnicity or anxiety traits. Conclusions: This meta-analysis provides evidence for sex and ethnicity differences in the association of the COMT val158met polymorphism with anxiety traits. Our findings contribute to current knowledge on the relation between prefrontal dopaminergic transmission and anxiety.