Quorum sensing - A novel target for the treatment of biofilm infections
Quorum sensing - A novel target for the treatment of biofilm infections
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DOI：
10.2165/00063030-200317040-00003
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发表时间：
2003-01-01
期刊：
影响因子：
6.8
通讯作者：
Givskov, M
中科院分区：
文献类型：
--
作者：
Hentzer, M;Eberl, L;Givskov, M
目前慢性感染的治疗是基于旨在杀死或抑制细菌生长的化合物。两个问题被认为与这种方法内在相关：（i）经常观察到的对抗微生物化合物的抗性的发展;和（ii）当与增殖细胞相比时，所有治疗剂对作为生物膜生长的细菌的有效性显著降低的事实。后一点特别重要，因为过去几年积累的证据表明，大多数慢性细菌感染都涉及生物膜。革兰氏阴性菌中细菌通讯系统（群体感应系统）的发现提供了一个新的机会，通过干扰生长以外的其他手段来控制感染细菌的活性，该细菌通讯系统被认为在感染过程中协调重要的时间事件，包括毒力因子的产生和生物膜的形成。干扰通信系统的化合物存在于自然界中。这些化合物不仅应该特异性地减弱毒力因子的产生，而且还应该以不太可能对抗性突变体的发展造成选择压力的方式影响生物膜形成。
Present-day treatment of chronic infections is based on compounds that aim to kill or inhibit growth of bacteria. Two problems are recognised to be intrinsically associated with this approach: (i) the frequently observed development of resistance to antimicrobial compounds; and (ii) the fact that all therapeutics are considerably less effective on bacteria growing as biofilms when compared with planktonic cells. The latter point is of particular importance as evidence has accumulated over the past few years that most chronic bacterial infections involve biofilms. The discovery of bacterial communication systems (quorum sensing systems) in Gram-negative bacteria which are believed to orchestrate important temporal events during the infectious process, including the production of virulence factors and the formation of biofilms, has afforded a novel opportunity to control the activity of infecting bacteria by other means than interfering with growth. Compounds that interfere with communication systems are present in nature. Such compounds should not only specifically attenuate the production of virulence factors but should also affect biofilm formation in a manner that is unlikely to pose a selective pressure for the development of resistant mutants.