Silicon and aluminium interactions in haemodialysis patients
Silicon and aluminium interactions in haemodialysis patients
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DOI：
10.1093/ndt/13.7.1759
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发表时间：
1998-07-01
影响因子：
6.1
通讯作者：
Altmann, P
中科院分区：
文献类型：
--
作者：
Parry, R;Plowman, D;Altmann, P
Background. Aluminium toxicity in dialysis patients is well described. Aluminium has a close chemical affinity with silicon. Silicon may have a role in protection against aluminium toxicity.Methods. We measured serum aluminium and silicon levels from haemodialysis patients from four different centres.Results. Though no relationship was seen across all centres combined, in one centre there was a reciprocal relationship in patients on home haemodialysis (who did not require reverse osmosis). Median (range) aluminium levels were higher, 2.2 (0.4-9.6) mu mol/l when serum silicon was less than 150 mu mol/l, and lower, 1.1 (0.2-2.8) mu mol/l when serum silicon levels were greater than 150 mu mol/l (P=0.03).Conclusions. In patients treated by haemodialysis without reverse osmosis high serum silicon concentrations were associated with lower serum aluminium concentrations than those with low serum silicon. Further work needs to confirm a preventative role for silicon in the accumulation and subsequent toxicity of aluminium in dialysis patients.
