Endocytosis and signalling: intertwining molecular networks.

Endocytosis and signalling: intertwining molecular networks.
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DOI:
10.1038/nrm2748
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发表时间:
2009-09
期刊:
Nature reviews. Molecular cell biology
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细胞信号传递和胞内膜转运传统上被视为不同的过程。虽然我们目前的认识还不完整,而且还存在很大的争议,但现在已经认识到,这些过程在动物细胞中是密切和双向联系的。事实上,最近的许多例子说明了内吞作用如何调节受体信号(包括来自受体酪氨酸激酶和G蛋白偶联受体的信号),反之,信号如何调节内吞途径。细胞生物学中信号传递和内吞作用之间关系的机制和功能原理在许多系统中正变得越来越明显。
Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct processes. Although our present understanding is incomplete and there are still great controversies, it is now recognized that these processes are intimately and bidirectionally linked in animal cells. Indeed, many recent examples illustrate how endocytosis regulates receptor signalling (including signalling from receptor tyrosine kinases and G protein-coupled receptors) and, conversely, how signalling regulates the endocytic pathway. The mechanistic and functional principles that underlie the relationship between signalling and endocytosis in cell biology are becoming increasingly evident across many systems.
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