C-reactive protein and rate of dementia in carriers and non carriers of Apolipoprotein APOE4 genotype
C-reactive protein and rate of dementia in carriers and non carriers of Apolipoprotein APOE4 genotype
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DOI：
10.1016/j.neurobiolaging.2007.04.020
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发表时间：
2008-12-01
影响因子：
4.2
通讯作者：
Jagust, William J.
中科院分区：
文献类型：
--
作者：
Haan, Mary N.;Aiello, Allison E.;Jagust, William J.
背景：携带载脂蛋白APOE 4等位基因（APOE 4）的人比不携带APOE 4的人C反应蛋白（CRP）低。APOE 4是否修改CRP的影响率的所有原因的痴呆症，认知功能障碍的阿尔茨海默氏病（AD）是没有established.Methods：所有原因的痴呆症和认知功能障碍无痴呆症（CIND）确定超过五个后续访问从1998年至2006年在一个正在进行的队列中的老年拉丁美洲人。高敏感性CRP和痴呆/CIND，所有原因的痴呆和阿尔茨海默病的APOE 4状态之间的关联进行了检查，在半参数生存模型与协变量adjustment.Results：CRP显着低于那些APOE 4比那些没有。在APO 4患者中，CRP与完全校正模型中痴呆/CIND的联合发生率较低相关（HR：0.60，95% CL：0.20-0.91，p=0.03）。在无APOE 4基因的人群中，CRP对痴呆/CIND的发生率无影响（HR：0.94，95%CL; 0.67-1.33）。结论：APOE 4基因型人群中CRP水平降低可能反映了APOE 4基因型的免疫效应。APOE 4患者的CRP升高可能是免疫功能较好的标志，导致痴呆和AD的发病率较低。(c)2007年爱思唯尔公司All rights reserved.
Background: The with an Apolipoprotein APOE4 allele (APOE4) have lower C-reactive protein (CRP) than those without APOE4. Whether APOE4 modifies the effects of CRP on rate of all cause dementia, cognitive impairment of Alzheimer's disease (AD) is not established.Methods: All cause dementia and cognitive impairment without dementia (CIND) was determined over five follow up visits from 1998 to 2006 in an ongoing cohort of older Latinos. The association between high sensitivity CRP and dementia/CIND, all cause dementia and Alzheimer's disease by APOE4 status was examined in semi-parametric survival models with covariate adjustments.Results: CRP was significantly lower among those with APOE4 than in those without. Among those with APO4, CRP was associated with lower rates of combined dementia/CIND (HR: 0.60, 95% CL:0.20-0.91, p=0.03) from a fully adjusted model. Among those with no APOE4, there was no effect of CRP on dementia/CIND rates (HR: 0.94, 95% CL; 0.67-1.33).Conclusions: Lower CRP in those with APOE4 may reflect immune effects of the APOE4 genotype. Higher CRP in those with APOE4 may be a marker of better immune function, leading to lower rate of dementia and AD. (c) 2007 Elsevier Inc. All rights reserved.