Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions.
Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions.
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DOI：
10.3389/fsurg.2016.00043
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发表时间：
2016
影响因子：
1.8
通讯作者：
Spetzler RF
中科院分区：
文献类型：
--
作者：
Fennell VS;Kalani MY;Atwal G;Martirosyan NL;Spetzler RF
了解颅内动脉瘤的生物学是一个临床难题。这些动脉瘤是如何形成、进展和破裂的，目前还知之甚少。证据表明，成熟的危险因素和免疫因素在其发展和临床结果中发挥着关键作用。随着对颅内动脉瘤的发生、发展和破裂的认识不断扩大，炎症是动脉瘤发病的关键介质。因此，利用动脉瘤发病机制的这一臂的治疗目标已经实施，通常具有良好的结果。
Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Thus, therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes.