Impact of DNA Oxidation on Toxicology: From Quantification to Genomics.

Impact of DNA Oxidation on Toxicology: From Quantification to Genomics.
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DOI:
10.1021/acs.chemrestox.9b00046
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发表时间:
2019-02
影响因子:
4.1
通讯作者:
Junzhou Wu;S. Sturla;C. Burrows;A. Fleming
Junzhou Wu;S. Sturla;C. Burrows;A. Fleming
中科院分区:
医学3区
文献类型:
--
作者:
Junzhou Wu;S. Sturla;C. Burrows;A. Fleming

文献摘要

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了解细胞氧化应激引起的脱氧核糖核酸(DNA)氧化的毒理学意义取决于识别DNA氧化产物,它们在基因组中的位置,以及它们与修复,复制和基因表达的相互作用。
Understanding the toxicological implications of deoxyribonucleic acid (DNA) oxidation arising from cellular oxidative stress depends on identifying DNA oxidation products, their location in the genome, and their interaction with repair, replication, and gene expression.