POTENTIAL OF THE SCID MOUSE AS A HOST FOR HUMAN TUMORS
POTENTIAL OF THE SCID MOUSE AS A HOST FOR HUMAN TUMORS
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DOI：
10.1007/bf00050791
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发表时间：
1991-10-01
影响因子：
9.2
通讯作者：
REISFELD, RA
中科院分区：
文献类型：
--
作者：
MUELLER, BM;REISFELD, RA
人类肿瘤及其转移的动物模型，有效地模拟临床疾病的需求是相当大的。虽然胸腺裸鼠确实为我们在体内研究大量人类肿瘤提供了有用的模型，但众所周知，裸鼠通常不会发生自发转移，也不适合所有类型的肿瘤。因此，允许许多人类肿瘤播散性生长的scid小鼠，特别是血液系统疾病和恶性黑色素瘤，可以优先用于这类恶性肿瘤的研究。在体内模型中研究人类免疫细胞和人类肿瘤相互作用的潜力是scid小鼠的另一个独特特征，这将增加它们在实验性癌症研究中的用处。
Animal models of human tumors and their metastases that effectively mimic clinical disease are in considerable demand. While it is certainly true that athymic nude mice provide us with useful models to study a large number of human tumors in vivo, it is also well known that nude mice usually do not develop spontaneous metastases and are not suitable for all types of tumors. Therefore, the scid mouse that allows disseminated growths for a number of human tumors, particularly hematologic disorders and malignant melanoma, can be used preferentially for the investigation of such malignancies. The potential to study the interaction of human immune cells and human tumor in an in vivo model is another unique feature of scid mice that will add to their usefulness in experimental cancer research.