Prophylactic Ephedrine Attenuates the Hemodynamic Response to Propofol in Elderly Female Patients
Prophylactic Ephedrine Attenuates the Hemodynamic Response to Propofol in Elderly Female Patients
复制标题
预防性麻黄碱减弱老年女性患者对异丙酚的血流动力学反应
DOI：
10.1213/00000539-199803000-00004
复制
发表时间：
1998
影响因子：
5.7
通讯作者：
M. Bentzon
中科院分区：
文献类型：
--
作者：
I. Michelsen;H. S. Helbo;F. Kohler;A. Lorenzen;Else Rydlund;M. Bentzon
In this study, we compared the effect of prophylactic administration of ephedrine against the hypotensive effect of propofol in elderly female patients scheduled for minor gynecological procedures.Ninety patients aged 60 yr or older were randomly allocated to one of three groups of 30 patients each to receive either normal saline, ephedrine 0.1 mg/kg, or ephedrine 0.2 mg/kg IV 1 min before the induction of anesthesia. Anesthesia was induced and maintained with propofol and fentanyl. Hemodynamic variables were measured before and 2, 5, 10, 15, 30, and 60 min after induction. The decrease in blood pressure and heart rate (HR) was significantly less in each of the ephedrine groups (P < 0.001). Furthermore, the decrease was less in the large-dose group compared with the small-dose group (P < 0.05). Twelve patients in the control group experienced a decrease in systolic blood pressure to <80 mm Hg, compared with only one patient in the ephedrine groups (P < 0.001). In conclusion, the prophylactic injection of ephedrine significantly attenuated, but did not completely abolish, the decrease in blood pressure associated with induction of anesthesia with fentanyl and propofol. Ephedrine 0.2 mg/kg was slightly more effective than ephedrine 0.1 mg/kg. Implications: The prophylactic effect of ephedrine to counteract the hypotensive effect of propofol induction of anesthesia was investigated in three groups of elderly female patients given 0.1 or 0.2 mg of ephedrine or placebo before induction. Both ephedrine doses markedly attenuated, but neither of them abolished, the decrease in blood pressure. (Anesth Analg 1998;86:477-81)
