Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities.
Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities.
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DOI：
10.3389/fnins.2021.650785
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发表时间：
2021
影响因子：
4.3
通讯作者：
Neisewander JL
中科院分区：
文献类型：
--
作者：
Namba MD;Leyrer-Jackson JM;Nagy EK;Olive MF;Neisewander JL
最近对药物滥用的神经生物学研究表明，神经免疫信号作为药物滥用诱导突触可塑性异常改变和促进药物滥用相关行为的机制具有重要作用。大脑和外周的免疫信号对神经系统的动态平衡起着至关重要的调节作用。免疫信号的紊乱可导致神经炎症或免疫抑制，导致神经系统功能失调，包括与物质使用障碍(SUDS)相关的神经过程。在这篇综述中，我们讨论了神经免疫信号在调节学习、记忆和突触可塑性中的作用的文献，强调中枢神经系统中的特定细胞因子信号。然后，我们重点介绍最近的临床前研究，如果可能的话，这些研究已经确定了大脑和外周与成瘾相关行为相关的免疫机制。到目前为止的研究结果强调了未来需要研究免疫药理学作为治疗肥胖症的一种新方法的临床潜力。考虑到肥胖症患者的高患病率，我们还讨论了与肥胖症相关的常见合并症的神经免疫机制，并强调了针对这些合并症的潜在的新的治疗目标。我们认为，免疫药理学代表了开发新药物疗法的新前沿，这些药物疗法可以促进长期戒毒，并最大限度地减少SUD合并症对患者健康和治疗结果的不利影响。
Recent studies examining the neurobiology of substance abuse have revealed a significant role of neuroimmune signaling as a mechanism through which drugs of abuse induce aberrant changes in synaptic plasticity and contribute to substance abuse-related behaviors. Immune signaling within the brain and the periphery critically regulates homeostasis of the nervous system. Perturbations in immune signaling can induce neuroinflammation or immunosuppression, which dysregulate nervous system function including neural processes associated with substance use disorders (SUDs). In this review, we discuss the literature that demonstrates a role of neuroimmune signaling in regulating learning, memory, and synaptic plasticity, emphasizing specific cytokine signaling within the central nervous system. We then highlight recent preclinical studies, within the last 5 years when possible, that have identified immune mechanisms within the brain and the periphery associated with addiction-related behaviors. Findings thus far underscore the need for future investigations into the clinical potential of immunopharmacology as a novel approach toward treating SUDs. Considering the high prevalence rate of comorbidities among those with SUDs, we also discuss neuroimmune mechanisms of common comorbidities associated with SUDs and highlight potentially novel treatment targets for these comorbid conditions. We argue that immunopharmacology represents a novel frontier in the development of new pharmacotherapies that promote long-term abstinence from drug use and minimize the detrimental impact of SUD comorbidities on patient health and treatment outcomes.
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影响因子：
9.3
作者：
Allison, David J.;Ditor, David S.
通讯作者：
Ditor, David S.
影响因子：
5.3
作者：
Alfonso-Loeches, Silvia;Pascual-Lucas, Maya;Guerri, Consuelo
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影响因子：
3.7
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影响因子：
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通讯作者：
Barve S
影响因子：
3.4
作者：
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通讯作者：
Sari, Youssef