Copper-Catalyzed Intermolecular Dehydrogenative Amidation/Amination of Quinoline N-Oxides with Lactams/Cyclamines
Copper-Catalyzed Intermolecular Dehydrogenative Amidation/Amination of Quinoline N-Oxides with Lactams/Cyclamines
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DOI：
10.1021/ol402324v
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发表时间：
2013-10-18
期刊：
影响因子：
5.2
通讯作者：
Sun, Kai
中科院分区：
文献类型：
--
作者：
Li, Gang;Jia, Chunqi;Sun, Kai
在Cu(OAc)(2)催化剂的存在下，喹啉n -氧化物与内酰胺/环胺进行了C-H， N-H脱氢偶联反应，得到了较好的收率。本研究为通过芳基C-H键直接功能化构建2-氨基喹啉骨架提供了一种新策略。
C-H, N-H dehydrogenative coupling of quinoline N-oxides with lactams/cyclamines has been achieved in the presence of the Cu(OAc)(2) catalyst to give good to excellent yields. This study provides a new strategy for the construction of a 2-aminoquinoline skeleton via direct functionalization of aryl C-H bonds.