A brief review on Group A Streptococcus pathogenesis and vaccine development.
A brief review on Group A Streptococcus pathogenesis and vaccine development.
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DOI：
10.1098/rsos.201991
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发表时间：
2021-03-10
影响因子：
3.5
通讯作者：
Dorfmueller HC
中科院分区：
文献类型：
--
作者：
Castro SA;Dorfmueller HC
化脓性链球菌（Streptococcus pyogenes），也称为A组链球菌（Group A Streptococcus，GAS），是革兰氏阳性的人类专属病原体，每年在全世界造成超过50万人死亡。感染后，GAS通常会引发轻微症状，如咽炎，化脓和发烧。然而，反复感染或长期暴露于GAS可能会导致危及生命的疾病。坏死性筋膜炎、链球菌中毒性休克综合征和免疫后介导的疾病，如链球菌感染后肾小球肾炎、急性风湿热和风湿性心脏病，是非工业化国家极高死亡率的原因。虽然在高收入国家观察到GAS感染的初步减少，但在过去十年中，已报告了GAS的全球爆发，引起风湿热和急性链球菌感染后肾小球肾炎。与此同时，我们对GAS发病机制和传播的理解大大增加，详细了解了感染的各个阶段，从宿主免疫系统的粘附，定植和逃避开始。尽管对GAS对人体的影响有了更深入的了解，但用于预防GAS的成功疫苗的开发仍然悬而未决。在这篇综述中，我们讨论了识别通用GAS疫苗所面临的挑战，并描述了几种我们认为值得追求的潜在疫苗候选物。
Streptococcus pyogenes, also known as Group A Streptococcus (GAS), is a Gram-positive human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide. Upon infection, GAS commonly triggers mild symptoms such as pharyngitis, pyoderma and fever. However, recurrent infections or prolonged exposure to GAS might lead to life-threatening conditions. Necrotizing fasciitis, streptococcal toxic shock syndrome and post-immune mediated diseases, such as poststreptococcal glomerulonephritis, acute rheumatic fever and rheumatic heart disease, contribute to very high mortality rates in non-industrialized countries. Though an initial reduction in GAS infections was observed in high-income countries, global outbreaks of GAS, causing rheumatic fever and acute poststreptococcal glomerulonephritis, have been reported over the last decade. At the same time, our understanding of GAS pathogenesis and transmission has vastly increased, with detailed insight into the various stages of infection, beginning with adhesion, colonization and evasion of the host immune system. Despite deeper knowledge of the impact of GAS on the human body, the development of a successful vaccine for prophylaxis of GAS remains outstanding. In this review, we discuss the challenges involved in identifying a universal GAS vaccine and describe several potential vaccine candidates that we believe warrant pursuit.
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影响因子：
3.7
作者：
Cunningham, Madeleine W.
通讯作者：
Cunningham, Madeleine W.
影响因子：
11.8
作者：
Bisno, AL;Rubin, FA;Dale, JB
通讯作者：
Dale, JB
影响因子：
3.1
作者：
Baums, Christoph G.;Kaim, Ute;Valentin-Weigand, Peter
通讯作者：
Valentin-Weigand, Peter
影响因子：
15.9
作者：
Ashbaugh, CD;Warren, HB;Wessels, MR
通讯作者：
Wessels, MR
DOI：
10.1074/mcp.m111.015693
发表时间：
2012-06
期刊：
Molecular & cellular proteomics : MCP
影响因子：
--
作者：
Bensi G;Mora M;Tuscano G;Biagini M;Chiarot E;Bombaci M;Capo S;Falugi F;Manetti AG;Donato P;Swennen E;Gallotta M;Garibaldi M;Pinto V;Chiappini N;Musser JM;Janulczyk R;Mariani M;Scarselli M;Telford JL;Grifantini R;Norais N;Margarit I;Grandi G
通讯作者：
Grandi G