Arylazido aminopropionyl atp (ANAPP3) antagonism of cat urinary bladder contractions.
Arylazido aminopropionyl atp (ANAPP3) antagonism of cat urinary bladder contractions.
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芳基叠氮氨基丙酰 atp (ANAPP3) 拮抗猫膀胱收缩。
DOI：
10.1111/j.1474-8673.1982.tb00487.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
TheobaldJr,RJ
中科院分区：
文献类型：
--
作者：
TheobaldJr,RJ
ANAPP 3产生猫膀胱的短暂收缩，类似于ATP和腹下神经刺激产生的收缩。2ANAPP 3部分拮抗腺苷对盆神经诱发的膀胱收缩的抑制作用，可能与阻断P1受体有关。3. ANAPP 3拮抗ATP、β，γ-亚甲基ATP、刺激盆神经和刺激腹下神经引起的猫膀胱收缩。4. ANAPP 3对去甲肾上腺素诱导的抑制盆腔神经诱发的膀胱收缩或乙酰胆碱诱导的膀胱收缩均不产生拮抗作用，从而证实了ANAPP 3对嘌呤的作用的特异性。
ANAPP3 produces a transient contraction of the urinary bladder of the cat similar to that produced by ATP and hypogastric nerve stimulation. 2 ANAPP3 partially antagonizes the inhibition of pelvic nerve-evoked bladder contractions induced by adenosine, possibly by blocking P1 receptors. 3 ANAPP3 antagonizes contractions of the cat urinary bladder induced by ATP, beta, gamma-methylene ATP, pelvic nerve stimulation and hypogastric nerve stimulation. 4 ANAPP3 produces no antagonism of either noradrenaline-induced inhibition of pelvic nerve-evoked bladder contractions or acetylcholine-induced bladder contractions, thereby substantiating the specificity of the effect of ANAPP3 against purines.