Spatial working memory deficit correlates with disorganization symptoms and social functioning in schizophrenia
Spatial working memory deficit correlates with disorganization symptoms and social functioning in schizophrenia
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DOI：
10.1111/j.1440-1819.2005.01398.x
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发表时间：
2005-08
影响因子：
11.9
通讯作者：
Hidetoshi Takahashi;M. Iwase;T. Nakahachi;Ryuji Sekiyama;K. Tabushi;O. Kajimoto;A. Shimizu;M. Takeda
中科院分区：
文献类型：
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作者：
Hidetoshi Takahashi;M. Iwase;T. Nakahachi;Ryuji Sekiyama;K. Tabushi;O. Kajimoto;A. Shimizu;M. Takeda
空间工作记忆缺陷和组织紊乱症状被认为是与背外侧前额皮质有关的精神分裂症损伤的重要组成部分。摘要本研究旨在探讨精神分裂症患者的空间工作记忆、精神症状（包括紊乱症状）和社会功能之间的关系。50名临床稳定的精神分裂症患者和34名健康对照者参加了这项研究。采用简易精神病学评定量表和康复评估Hall和Baker量表对患者进行评定。空间工作记忆的评价采用“进阶轨迹测验”。与健康对照组相比，患者表现出明显的空间工作记忆下降。患者的空间工作记忆与社会功能（如自我照顾技能、社区技能和言语障碍）以及紊乱症状显著相关。紊乱症状也与社会功能的这些方面相关。综上所述，空间工作记忆缺陷和组织紊乱症状是与背外侧前额叶皮质功能障碍相关的障碍，可以作为社会功能障碍的有效预测因子。
Abstract Both spatial working memory deficit and disorganization symptoms have been considered significant components of schizophrenic impairment involved with the dorsolateral prefrontal cortex. The purpose of the present study was to investigate the relationships among spatial working memory, psychiatric symptoms including disorganization symptoms, and social functioning in schizophrenia. Fifty clinically stable patients with schizophrenia and 34 healthy controls participated in the study. Patients were rated with the Brief Psychiatric Rating Scale and the Rehabilitation Evaluation Hall and Baker. The Advanced Trail Making Test was used to evaluate spatial working memory. Patients demonstrated significantly reduced spatial working memory compared to that of healthy controls. Spatial working memory in patients correlated significantly with social functioning such as self‐care skills, community skills and speech disturbance, and with disorganization symptoms. Disorganization symptoms also correlated with these aspects of social functioning. In conclusion it is suggested that both spatial working memory deficit and disorganization symptoms, which are impairments involved with the dorsolateral prefrontal cortex dysfunction, can serve as effective predictors of social functioning.