Effects of moderate-to-vigorous intensity physical activity on overnight and next-day hypoglycemia in active adolescents with type 1 diabetes.
Effects of moderate-to-vigorous intensity physical activity on overnight and next-day hypoglycemia in active adolescents with type 1 diabetes.
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DOI：
10.2337/dc13-1973
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发表时间：
2014
期刊：
影响因子：
16.2
通讯作者：
Janz KF
中科院分区：
文献类型：
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作者：
Metcalf KM;Singhvi A;Tsalikian E;Tansey MJ;Zimmerman MB;Esliger DW;Janz KF
体力活动（PA）为1型糖尿病青少年提供了许多益处;然而，这些人的健康和PA水平往往低于无病青少年。本研究的目的是检查中度至剧烈强度PA（MVPA）与低血糖（连续血糖监测仪[CGM]阅读≤70 mg/dL）之间的急性时间相关性。招募了19名14-20岁的1型糖尿病患者（53%为女性）。通过间接热量测定法使用最大运动试验评估参与者的健康状况;使用空气置换体积描记法测量身体成分。连续佩戴加速度计（3-5天），加速度数据用于估计MVPA（每天分钟数）。使用CGM同时跟踪血糖值。控制性别、体脂百分比（%BF）、健身和并发MVPA，使用logistic回归分析MVPA导致夜间和次日低血糖的可能性。受试者的平均健身率（女性：43.9 mL/kg/min;男性：49.8 mL/kg/min）和肥胖率（女性：26.2%;男性：19.2%）; 63.2%符合美国联邦指南，即累积60分钟/天的MVPA。在前一天下午累积MVPA 30分钟/天的患者中，低血糖的可能性比累积MVPA 30分钟/天的患者高31%（95% CI 1.05-1.63; P = 0.017）。结果表明，参加下午MVPA会增加夜间和第二天低血糖的风险，与性别、%BF、健身和并发MVPA无关。在促进PA作为一种健康行为的同时，重要的是要教育青少年1型糖尿病患者预防PA后低血糖。
Physical activity (PA) provides many benefits to adolescents with type 1 diabetes; however, these individuals tend to have lower fitness and PA levels than their disease-free counterparts. The purpose of this study was to examine the acute temporal associations between moderate-to-vigorous intensity PA (MVPA) and hypoglycemia (continuous glucose monitor [CGM] reading ≤70 mg/dL). Nineteen participants (53% females) 14–20 years old with type 1 diabetes were recruited. Participant fitness was evaluated via indirect calorimetry using a maximal exercise test; body composition was measured using air displacement plethysmography. An accelerometer was worn continuously (3–5 days) and acceleration data used to estimate MVPA (minutes per day). Blood glucose values were simultaneously tracked using CGM. Controlling for sex, percent body fat (%BF), fitness, and concurrent MVPA, the likelihood of nighttime and next-day hypoglycemia due to MVPA was examined using logistic regression. Participants were of average fitness (females: 43.9 mL/kg/min; males: 49.8 mL/kg/min) and adiposity (females: 26.2%; males: 19.2%); 63.2% met the U.S. federal guideline of accumulating 60 min/day of MVPA. Hypoglycemia was 31% more likely in those who accumulated 30 min/day more MVPA in the previous afternoon than those with less (95% CI 1.05–1.63; P = 0.017). The results suggest that participating in afternoon MVPA increases the risk of overnight and next-day hypoglycemia, independent of sex, %BF, fitness, and concurrent MVPA. While promoting PA as a healthy behavior, it is important to educate adolescents with type 1 diabetes on prevention of hypoglycemia following PA.