Highly enantioselective cascade synthesis of spiropyrazolones
Highly enantioselective cascade synthesis of spiropyrazolones
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DOI：
10.1039/c1ob05753g
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
Rios, Ramon
中科院分区：
文献类型：
--
作者：
Zea, Alex;Alba, Andrea-Nekane R.;Rios, Ramon
描述了基于有机催化的螺吡唑啉酮的有效合成。吡唑啉酮、烯醇化醛和烯醛之间的反应由仲胺催化剂催化，并以良好的产率和优异的非对映和对映选择性提供带有四个连续手性中心的最终螺环化合物。
An efficient synthesis of spiropyrazolones based on organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo- and enantioselectivities.