Asymmetric epoxidation catalyzed by alpha,alpha-dimethylmorpholinone ketone. Methyl group effect on spiro and planar transition states.
Asymmetric epoxidation catalyzed by alpha,alpha-dimethylmorpholinone ketone. Methyl group effect on spiro and planar transition states.
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DOI：
10.1021/jo900739q
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发表时间：
2009-07
期刊：
影响因子：
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通讯作者：
O. A. Wong;Bin Wang;Mei-Xin Zhao;Yian Shi
中科院分区：
文献类型：
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作者：
O. A. Wong;Bin Wang;Mei-Xin Zhao;Yian Shi
研究了含α，α-二甲基吗啉酮的手性酮催化剂（4）催化烯烃的不对称环氧化反应。这种酮，它有几个以前研究的催化剂的组合功能，是一种有效的催化剂，反式和三取代烯烃，并已达到高达97%ee。α，α-二甲基基团对螺环和平面过渡态具有显著影响。
Asymmetric epoxidation of olefins by using an alpha,alpha-dimethylmorpholinone-containing chiral ketone catalyst (4) has been investigated. This ketone, which has the combined features of several previously studied catalysts, is an effective catalyst for trans- and trisubstituted olefins, and up to 97% ee has been achieved. The alpha,alpha-dimethyl group has significant impact on spiro and planar transition states.