Three-Dimensional Printing Articular Cartilage: Recapitulating the Complexity of Native Tissue
Three-Dimensional Printing Articular Cartilage: Recapitulating the Complexity of Native Tissue
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DOI：
10.1089/ten.teb.2016.0316
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发表时间：
2017-06-01
影响因子：
6.4
通讯作者：
Fisher, John P.
中科院分区：
文献类型：
--
作者：
Guo, Ting;Lembong, Josephine;Fisher, John P.
在过去的几十年里，组织工程领域结合快速成型（RP）技术已经成功地创造了模仿组织的生物替代品。它在再生医学中的应用吸引了来自各个科学领域，诊断学和临床转化为治疗的研究。虽然一些治疗领域已经发展得很好，例如皮肤置换，但由于目前现有的通常是手术治疗的低成功率和/或低效率，许多其他领域例如软骨修复仍然可以从组织工程和RP中受益匪浅。通过复杂支架的制造和先进材料的开发，RP为软骨修复提供了新的途径。计算机辅助设计和三维（3D）打印允许制造用于修复和再生受损软骨组织的模型软骨支架。具体来说，将详细讨论3D打印的各种过程，包括细胞和非细胞技术，涵盖不同的材料，几何形状和组织工程化关节软骨开发的操作打印条件。最后，我们总结了与这项技术相关的未来应用和挑战的一些见解，特别是使用3D打印技术来概括高级软骨再生的天然结构的复杂性。
In the past few decades, the field of tissue engineering combined with rapid prototyping (RP) techniques has been successful in creating biological substitutes that mimic tissues. Its applications in regenerative medicine have drawn efforts in research from various scientific fields, diagnostics, and clinical translation to therapies. While some areas of therapeutics are well developed, such as skin replacement, many others such as cartilage repair can still greatly benefit from tissue engineering and RP due to the low success and/or inefficiency of current existing, often surgical treatments. Through fabrication of complex scaffolds and development of advanced materials, RP provides a new avenue for cartilage repair. Computer-aided design and three-dimensional (3D) printing allow the fabrication of modeled cartilage scaffolds for repair and regeneration of damaged cartilage tissues. Specifically, the various processes of 3D printing will be discussed in details, both cellular and acellular techniques, covering the different materials, geometries, and operational printing conditions for the development of tissue-engineered articular cartilage. Finally, we conclude with some insights on future applications and challenges related to this technology, especially using 3D printing techniques to recapitulate the complexity of native structure for advanced cartilage regeneration.