COMPARISON OF THE GENES-CODING FOR THE COMMON 5' TERMINAL SEQUENCE OF MESSENGER-RNAS IN 3 TRYPANOSOME SPECIES
COMPARISON OF THE GENES-CODING FOR THE COMMON 5' TERMINAL SEQUENCE OF MESSENGER-RNAS IN 3 TRYPANOSOME SPECIES
复制标题
DOI：
10.1093/nar/12.11.4431
复制
发表时间：
1984-01-01
影响因子：
14.9
通讯作者：
BORST, P
中科院分区：
文献类型：
--
作者：
DELANGE, T;BERKVENS, TM;BORST, P
Messenger RNAs ofTrypanosoroa bruceishare a common 5′ terminal sequence of 35 nucleotides, encoded by a mini-exon located in 1.35-kb tandemly linked repeats. We show here that sequences, almost identical to the mini-exon ofT.brucei, are present in mRNAs from members of two other kinetoplastid subgenera:Trypanosoma vivaxandTrypanosoma cruzi. As inT.brucei, these mini-exons are encoded by small tandemly linked repeat elements. We have determined and compared the nucleotide sequences of the mini-exon repeats fromT.brucei,T.vivaxandT.cruzi. This analysis shows that the mini-exon, its immediate flanking sequences and a T-rich stretch downstream are conserved, but little else Our data establish the generality of the novel transcription system, that was first found inT.bruceiand that yields mRNAs with common, repeat-encoded, 5′ termini.
