Chemokine/chemokine receptor nomenclature.
Chemokine/chemokine receptor nomenclature.
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DOI：
10.1089/107999002760624305
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发表时间：
2002-10
影响因子：
2.2
通讯作者：
K. Bacon;M. Baggiolini;H. Broxmeyer;R. Horuk;I. Lindley;A. Mantovani;K. Maysushima;P. Murphy;
中科院分区：
文献类型：
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作者：
K. Bacon;M. Baggiolini;H. Broxmeyer;R. Horuk;I. Lindley;A. Mantovani;K. Maysushima;P. Murphy;
趋化因子包含一个大的蛋白质家族，可以根据结构基序分为多个亚家族。趋化因子的共同特性是白细胞趋化性。直到最近，趋化因子的命名都是随机的，没有使用明确的系统。一些已包含在白细胞介素中（例如IL-8），另一些已被赋予描述功能的名称，例如巨噬细胞趋化蛋白。另一些是根据产生趋化因子的细胞类型来命名的，例如血小板因子 4，而另一些则是任意命名的。在某些情况下，所选择的名称使用起来很麻烦，这导致这些趋化因子几乎总是通过名称的缩写形式来引用，例如 RANTES。许多趋化因子显示出重叠的功能，这在识别与特定实验观察相关的分子时造成了一些混乱。趋化因子通过与一大家族的 7 次跨膜 G 蛋白偶联受体相互作用来介导其生物效应。尽管每种受体亚型通常结合多种趋化因子，但其特异性受到趋化因子亚家族的限制。这就产生了一个逻辑受体命名系统，其中每个受体都由趋化因子亚家族名称（C、CC、CXC、CX3C）指定，后跟表示“受体”的字母“R”和一个数字（基于其被识别的时间顺序）。该系统自 1996 年开始实施，并得到了国际药理学联盟命名委员会的正式认可（Pharmacol. Rev. 52, 145–176 [2000]）。在某些情况下，CD编号已分配给特定的趋化因子受体，而CD181-CD199块已被保留以供此类受体将来使用（见表）。 Yoshie 和 Zlotnik 设计了一个系统命名法，与最近发表的受体命名法系统平行（Immunity 12, 121–127 [2000]）。国际免疫学会联盟命名委员会的趋化因子命名小组委员会已经考虑了该系统，并建议 IUIS/WHO 采用该系统。该系统概述如表所示。建议那些希望与历史命名法保持联系的科学家在系统名称后的括号中引用这一点。该表是系统的更新版本。
THE CHEMOKINES COMPRISE a large protein family that can be divided into subfamilies on the basis of structural motifs. The common property of chemokines is leukocyte chemotaxis. Until recently, chemokines have been named randomly, with no clear system being used. Some have been included with the interleukins (eg, IL-8), and others have been given names describing a function, for example, macrophage chemotactic proteins. Others have been named according to the cell type that produces the chemokine, for example, platelet factor 4, whereas others have been named arbitrarily. In some cases, the names that have been chosen are cumbersome to use, which has resulted in these chemokines being almost always referenced by an abbreviated form of the name, for example, RANTES. Many chemokines show overlapping functions, and this has caused some confusion in identifying the molecules associated with particular experimental observations. Chemokines mediate their biologic effects via interactions with a large family of 7-transmembrane G protein-coupled receptors. Although each receptor subtype typically binds multiple chemokines, the specificity is restricted by chemokine subfamily. This has led to a logical receptor nomenclature system in which each receptor is designated by chemokine subfamily name (C, CC, CXC, CX3C) followed by the letter “R” designating “receptor” and a number, based on the chronologic order in which it was identified. This system has been in place since 1996 and has been officially endorsed by the Nomenclature Committee of the International Union of Pharmacology (Pharmacol. Rev. 52, 145–176 [2000]). In some cases, CD numbers have been assigned to particular chemokine receptors, and the block CD181–CD199 has been reserved for future use for such receptors (see Table).In an attempt to clarify, if not solve, the now confused and complex nomenclature associated with chemokines, Drs. Yoshie and Zlotnik have devised a systematic nomenclature paralleling that of the receptor nomenclature system recently published (Immunity 12, 121–127 [2000]). The Chemokine Nomenclature Subcommittee of the Nomenclature Committee of the International Union of Immunological Societies has considered this system and recommended its adoption by IUIS/WHO. The system is outlined in the Table. Those scientists wishing to maintain a linkage with the historical nomenclature are recommended to quote this in brackets after the systematic name. The Table is an updated version of the system.