Temporal and Demographic Trends in Glomerular Disease Epidemiology in the Southeastern United States, 1986-2015
Temporal and Demographic Trends in Glomerular Disease Epidemiology in the Southeastern United States, 1986-2015
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DOI：
10.2215/cjn.10871016
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发表时间：
2017-04-01
影响因子：
9.8
通讯作者：
Jennette, J. Charles
中科院分区：
文献类型：
--
作者：
O'Shaughnessy, Michelle M.;Hogan, Susan L.;Jennette, J. Charles
背景和目的在美国，目前还缺乏大规模的肾小球疾病流行病学研究。我们的目的是确定美国东南部肾活检肾小球疾病诊断频率的30年时间和人口统计学趋势。设计、设置、参与者和测量在这项横断面观察性研究中，我们确定了所有患者的自体肾活检标本，显示18种被广泛认可的肾小球疾病诊断之一，这些诊断被提交给北卡罗来纳州查佩尔山大学肾脏病理学分部在1986年到2015年间活检时代（1986-1995年、1996-2005年和2006-2015年）和人口统计数据（年龄、性别和种族）分别是我们的主要和次要预测因素，每种肾小球疾病诊断的相对频率是我们的主要结果。（平均年龄=48.3 ± 18.3岁; 50.8%为男性; 56.8%为白色; 38.3%为黑人; 2.8%为拉丁裔; 1.4%为亚裔; 0.8%其他），肾活检标本中糖尿病性肾小球硬化的频率在三十年中急剧增加（5.5%，11.4%，和19.1%的诊断; P为趋势
Background and objectives Large-scale, contemporary studies exploring glomerular disease epidemiology in the United States are lacking. We aimed to determine 30-year temporal and demographic trends in renal biopsy glomerular disease diagnosis frequencies in the southeastern United States.Design, setting, participants, & measurements In this cross-sectional, observational study, we identified all patients with a native kidney biopsy specimen showing one of 18 widely recognized glomerular disease diagnoses referred to the University of North Carolina Chapel Hill Division of Nephropathology between 1986 and 2015. Biopsy era (1986-1995, 1996-2005, and 2006-2015) and demographics (age, sex, and race) were our primary and secondary predictors, respectively, and the relative frequency of each glomerular disease diagnosis was our primary outcome.Results Among 21,374 patients (mean age =48.3 +/- 18.3 years old; 50.8% men; 56.8% white; 38.3% black; 2.8% Latino; 1.4% Asian; 0.8% other), the frequency of diabetic glomerulosclerosis in renal biopsy specimens increased dramatically over the three decades (5.5%, 11.4%, and 19.1% of diagnoses, respectively; P for trend