Are dendritic cells the key to liver transplant tolerance?

Are dendritic cells the key to liver transplant tolerance?
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树突状细胞是肝移植耐受的关键吗?

DOI:
10.1016/s0167-5699(98)01378-4
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发表时间:
1999
期刊:
Immunology today
影响因子:
--
通讯作者:
Lu,L
Lu,L
中科院分区:
--
文献类型:
--
作者:
Thomson,AW;Lu,L

文献摘要

被引文献

相似文献

肝脏移植物的固有致耐受性可能是由于器官的造血活性、生长促进和免疫调节细胞因子的产生以及相对大量的潜在致耐受性抗原呈递细胞(特别是树突状细胞(DC))的组合。在这里,安格斯汤姆森和丽娜卢认为证据表明,树突状细胞可以破坏同种异体T细胞反应,并可能在治疗上延长移植物的存活。
The inherent tolerogenicity of liver allografts could be due to the organ's combination of hematopoietic activity, production of growth-promoting and immunoregulatory cytokines, and comparatively large numbers of potentially tolerogenic antigen-presenting cells, in particular dendritic cells (DCs). Here, Angus Thomson and Lina Lu consider the evidence that DCs can subvert allogeneic T-cell responses and might be exploited therapeutically to prolong graft survival.