Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats
Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats
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DOI：
10.1007/s00198-009-0836-y
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发表时间：
2009-09-01
影响因子：
4
通讯作者：
Iwaniec, U. T.
中科院分区：
文献类型：
--
作者：
Maddalozzo, G. F.;Turner, R. T.;Iwaniec, U. T.
长期酗酒是骨质疏松症和肌肉减少症的危险因素，但酒精对未成熟肌肉骨骼系统的长期影响尚不清楚。本研究旨在确定饮酒对生长期大鼠的身体成分、肌肉质量、骨量、结构和周转率的影响。很少有研究关注饮酒对骨骼和肌肉在骨骼成熟过程中的长期影响。将酒精纳入4周龄雄性Sprague-Dawley大鼠的饮食中（35%热量摄入），持续3个月。对照组自由进食等热量无酒精的流质饮食。在第二项研究中，对照组与酒精喂养的动物配对喂养，与随意喂养的年龄匹配的对照组相比，酒精喂养的大鼠体重较轻，瘦体重、脂肪量和体脂百分比较低。此外，他们的慢肌和快肌质量较低，全身骨矿物质含量和骨矿物质密度较低，腰椎和胫骨近端松质骨体积较低。酒精消费对身体组成的影响减少时，对喂养的控制饮食相比，表明热量限制是一个合并症的因素。与此相反，酒精的影响，以减少骨形成和血清瘦素和IGF-I水平，并增加骨髓肥胖出现独立的热量restriction.The生长酒精喂养大鼠的骨骼异常是由于酒精消费和酒精引起的热量限制特定的影响相结合。
Chronic alcohol abuse is a risk factor for osteoporosis and sarcopenia, but the long-term effects of alcohol on the immature musculoskeletal system are less clear. The present investigation in growing rats was designed to determine the effects of alcohol consumption on body composition, muscle mass, and bone mass, architecture, and turnover.Few studies have focused on the long-term effects of drinking on bone and muscle during skeletal maturation.Alcohol was included in the diet of 4-week-old male Sprague-Dawley rats (35% caloric intake) for 3 months. The controls were fed an isocaloric alcohol-free liquid diet ad libitum. A second study was performed in which the controls were pair-fed to the alcohol-fed animals.Compared to ad libitum-fed age-matched controls, alcohol-fed rats weighed less and had lower lean mass, fat mass, and percent body fat. In addition, they had lower slow- and fast-twitch muscle mass, lower total body bone mineral content and bone mineral density, and lower cancellous bone volume in the lumbar vertebra and proximal tibia. The effects of alcohol consumption on body composition were reduced when compared to the pair-fed control diet, indicating that caloric restriction was a comorbidity factor. In contrast, the effects of alcohol to decrease bone formation and serum leptin and IGF-I levels and to increase bone marrow adiposity appeared independent of caloric restriction.The skeletal abnormalities in growing alcohol-fed rats were due to a combination of effects specific to alcohol consumption and alcohol-induced caloric restriction.