Evidence for activation of microglia in patients with psychiatric illnesses
Evidence for activation of microglia in patients with psychiatric illnesses
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DOI：
10.1016/s0304-3940(99)00545-5
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发表时间：
1999-08-20
影响因子：
2.5
通讯作者：
Falkai, P
中科院分区：
文献类型：
--
作者：
Bayer, TA;Buslei, R;Falkai, P
小胶质细胞/巨噬细胞的激活是中枢神经系统病理变化反应的关键事件。HLA-DR是一种有价值的免疫组织化学标记物，可与活化的小胶质细胞特异性反应。为了阐明小胶质细胞增生在严重精神疾病中的潜在作用，我们研究了精神分裂症（n = 14）和情感性障碍（n = 6）患者的死后额叶皮层和海马以及对照标本（n = 13）。此外，阿尔茨海默病病例（n = 8）被纳入具有典型神经退行性改变和小胶质细胞激活的人类模型系统。所有患者组均在灰质和白质中发现了丰富的小胶质细胞免疫染色（精神分裂症，3例；情感性障碍，1例；阿尔茨海默病，4例）。这一发现为精神分裂症和情感障碍患者大脑中明显的神经病理变化提供了证据。小胶质细胞的激活，代表了大脑免疫反应的主要部分，可能有助于揭示严重精神疾病的病理生理过程。1999爱思唯尔科学爱尔兰有限公司版权所有。
Activation of microglia/macrophages is a key event in response to pathological changes in the CNS. HLA-DR is a valuable immunohistochemical marker that specifically reacts with activated microglia cells. In order to elucidate a potential role of microgliosis in severe psychiatric illnesses, post-mortem frontal cortex and hippocampus of patients with schizophrenia (n = 14) and affective disorder (n = 6) and control specimens (n = 13) were studied. Additionally Alzheimer's disease cases (n = 8) were included as a human model system with typical neurodegenerative alterations and microglia activation. All patient groups revealed subjects with abundant microglia immunostaining (schizophrenia, three patients; affective disorder, one patient; Alzheimer's disease, four patients) in both gray and white matter. This finding provides evidence for distinct neuropathological changes in brains of patients with schizophrenia and affective disorder. The activation of microglia cells, which represent a major part of the brain immune response, may help to unravel the pathophysiological processes in severe psychiatric illnesses. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.