RETINOIC ACID REGULATES GROWTH-HORMONE GENE-EXPRESSION
RETINOIC ACID REGULATES GROWTH-HORMONE GENE-EXPRESSION
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DOI：
10.1038/339231a0
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发表时间：
1989-05-18
期刊：
影响因子：
64.8
通讯作者：
ARANDA, A
中科院分区：
文献类型：
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作者：
BEDO, G;SANTISTEBAN, P;ARANDA, A
正常生长和发育需要维生素 A，而视黄酸 (RA) 可能是该过程中的活性代谢物1。最近的证据表明，RA 通过与属于类固醇/甲状腺激素受体超家族的核受体 2-5 结合而发挥作用。这些受体似乎与靶基因中的激素反应元件相关，从而导致转录的激活（或抑制）。尽管尚未报道 RA 受体复合物与特定 DNA 序列的相互作用，但不同受体的同源性表明它们的作用机制相似。因此，我们研究了 RA 对生长的影响是否与生长激素基因表达的变化有关，已知生长激素基因受甲状腺激素和糖皮质激素的转录调节。我们的结果表明RA控制垂体GH1细胞中生长激素的产生并且其作用与这些激素引起的作用具有协同作用。
VITAMIN A is required for normal growth and development, and retinoic acid (RA) may be the active metabolite in this process1. Recent evidence indicates that RA acts through binding to a nuclear receptor2–5which belongs to the steroid/thyroid hormone receptor superfamily6. The receptors seem to associate with hormone-response elements in the target genes resulting in the activation (or inhibition) of transcription6. Although no interaction of RA–receptor complex with specific DNA sequences has yet been reported, the homology of the different receptors suggests their mechanisms of action are similar. We therefore examined whether the effects of RA on growth could be related to changes in the expression of the growth hormone gene which is known to be transcriptionally regulated by both thyroid and glucocorticoid hormones7. Our results show that RA controls growth hormone production in pituitary GHl cells and that its effect is synergistic with that caused by these hormones.