Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat
Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat
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DOI：
10.1292/jvms.71.817
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发表时间：
2009-06-01
影响因子：
1.2
通讯作者：
Tsujimoto, Hajime
中科院分区：
文献类型：
--
作者：
Ide, Kaori;Setoguchi-Mukai, Asuka;Tsujimoto, Hajime
一只10岁的日本家猫出现厌食和体重减轻。检测到重度贫血和血小板减少症。腹部放射线摄影及超音波检查发现脾脏有多个肿块。细胞学分析的群众揭示了一些非典型的组织细胞和相当大的噬血细胞。一个脾切除术进行，质量被诊断为组织细胞肉瘤的基础上，组织病理学，细胞化学和免疫组化分析。此外，在骨髓中观察到异常噬血细胞作用。猫给予泼尼松龙和洛莫司汀，入院后存活107天。尸检显示在骨髓、肝脏、胰腺淋巴结和肾小球中存在肿瘤组织细胞。这是在日本报道的第一例猫的组织细胞肉瘤。
A 10-year-old Japanese domestic cat was presented with anorexia and weight loss. Severe anemia and thrombocytopenia were detected. Abdominal radiography and Ultrasonography revealed the presence of multiple masses in the spleen. Cytological analyses of the masses revealed several atypical histiocytic cells and considerable hemophagocytosis. A splenectomy was performed, and the mass was diagnosed as histiocytic Sarcoma on the basis of histopathological, cytochemical and immunohistochemical analyses. Further, abnormal hemophagocytosis was observed in the bone marrow. The cat was administered prednisolone and lomustine, and it survived for 107 days after admission. An autopsy revealed the presence of neoplastic histiocytic cells in the bone marrow, liver, pancreatic lymph node and glomeruli. This is the first case of histiocytic Sarcoma in a cat to be reported in Japan.