Synthesis and characterization of surface-modified Fe3O4 super-paramagnetic nanoparticles
Synthesis and characterization of surface-modified Fe3O4 super-paramagnetic nanoparticles
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DOI：
10.1007/s11596-014-1270-8
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发表时间：
2014-04
期刊：
影响因子：
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通讯作者：
Zhan-jie Zhang;Jia Ma;Shuang-bing Xu;Jing-hua Ren;Y. Qin;Jing Huang;Kun-yu Yang;Zhi-ping Zhang;Gang Wu
中科院分区：
文献类型：
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作者：
Zhan-jie Zhang;Jia Ma;Shuang-bing Xu;Jing-hua Ren;Y. Qin;Jing Huang;Kun-yu Yang;Zhi-ping Zhang;Gang Wu
Aqueous dispersion and stability of Fe3O4nanoparticles remain an issue unresolved since aggregation of naked iron nanoparticles in water. In this study, we successfully synthesized different Fe3O4super-paramagnetic nanoparticles which were modified by three kinds of materials [DSPE-MPEG2000, TiO2and poly acrylic acid (PAA)] and further detected their characteristics. Transmission electron microscopy (TEM) clearly showed sizes and morphology of the four kinds of nanoparticles. X-ray diffraction (XRD) proved successfully coating of the three kinds of nanoparticles and their structures were maintained. Vibrating sample magnetometer (VSM) verified that their magnetic properties fitted for the super-paramagnetic function. More importantly, the particle size analysis indicated that Fe3O4@PAA had a better size distribution, biocompatibility, stability and dispersion than the other two kinds of nanoparticles. In addition, using CNE2 cells as a model, we found that all nanoparticles were nontoxic. Taken together, our data suggest that Fe3O4@PAA nanoaparticles are superior in the application of biomedical field among the four kinds of Fe3O4nanoparticles in the future.
