Identification of the thermo-physical properties of a stratified tissue. Adiabatic hypodermic wall
Identification of the thermo-physical properties of a stratified tissue. Adiabatic hypodermic wall
复制标题
分层组织的热物理特性的识别。
DOI：
10.1016/j.icheatmasstransfer.2021.105376
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发表时间：
2021
影响因子：
7
通讯作者：
Jitse Niesen
中科院分区：
文献类型：
--
作者：
M. Alosaimi;D. Lesnic;Jitse Niesen
生物组织具有难以直接测量的热物理性质，在检测到异常时，为了决定适当的治疗程序(如接种地点和适当的药物剂量)，这些性质的估计是非常重要的。在本文中，我们首次数值研究了一维、多层生物皮肤组织在外部加热下的几个热物理血液组织性质的确定。与通常假定热信号无限快速传播的抛物线模型不同，在本文中，生物体内的生物热传递用双曲型偏微分方程组进行数学建模，该方程考虑了热波速度是有限的。在皮肤表面，考虑到与环境的热交换，对流边界条件成立，而在组织的最内壁，应用绝热边界条件。然后，在这个框架中，通过最小化一个加权的非线性最小二乘目标函数，从多层组织内外边界上的非侵入性温度测量中准确和稳定地重建由热导率、热容和血液灌注率给定的分段恒定的热物理属性。
Biological living tissues possess thermophysical properties that are difficult to measure directly and their estimation is very important in order to decide the appropriate treatment procedure (e.g. place of inoculation and appropriate amount of drug dosage) in case an abnormality is detected. In the present paper, we numerically investigate, for the first time, the determination of several thermo-physical blood-tissue properties of a one-dimensional, multi-layered biological skin tissue subjected to external heating. In contrast to the usual parabolic model that assumes infinitely fast propagation of the heat signal, in the present paper, the bio-heat transfer in such a biological body is mathematically modelled by a hyperbolic partial differential equation, which takes into account that the thermal wave speed is finite. On the skin surface a convective boundary condition holds taking into account the heat exchange with the environment, whilst on the most inner wall of the tissue an adiabatic boundary condition applies. Then, in this framework, the piecewise constant thermo-physical properties of interest given by the thermal conductivity, heat capacity and blood perfusion rate are accurately and stably reconstructed from non-intrusive temperature measurements on the inner and outer boundaries of the multi-layered tissue by minimizing a weighted nonlinear least-squares objective function.
DOI：
10.1115/1.2891396
发表时间：
1992-08
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
C. Chan
通讯作者：
C. Chan