3-nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: Is 3-NPA in some plants produced by endophytes?
3-nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: Is 3-NPA in some plants produced by endophytes?
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DOI：
10.1021/np050036a
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发表时间：
2005-07-01
影响因子：
5.1
通讯作者：
Kittakoop, P
中科院分区：
文献类型：
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作者：
Chomeheon, P;Wiyakrutta, S;Kittakoop, P
3-在几种内生真菌的提取物中发现了硝基丙酸（3-NPA，1）。3-NPA（1）显示出有效的抗分枝杆菌活性，最小抑制浓度为3.3 μ M，但对NCI-H187、BC、KB和Vero细胞系无活性。发现内生菌产生高水平的3-NPA（1），因此在某些植物中积累的3-NPA（1）可能由相关的内生菌产生。3-NPA（1）可作为内生真菌的化学分类学标记。杀线虫剂3-羟基丙酸的结构应修改为3-NPA（1）。
3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 mu M, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1).