OpenSAFELY: Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England.
OpenSAFELY: Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England.
复制标题
DOI：
10.12688/wellcomeopenres.18010.1
复制
发表时间：
2022
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
背景资料：自2020年3月启用以来，OpenSAFELY-TPP电子健康记录平台的数据已用于20多项与全球COVID-19紧急情况相关的研究。OpenSAFELY-TPP数据来自英国使用SystmOne软件的实践，并已用于大多数研究。我们着手调查OpenSAFELY-TPP数据的代表性，将其与国家人口估计值进行比较。 研究方法：在NHS英格兰的批准下，我们描述了OpenSAFELY-TPP人口的年龄，性别，多重痴呆指数和种族，并与国家统计局的国家估计值进行了比较。2020年1月1日至2020年12月31日期间发生的五大死亡原因也与同期在英格兰登记的死亡人数进行了比较。 结果如下：尽管存在地区差异，TPP在IMD（均在1.1个百分点以内）、年龄、性别（0.1个百分点以内）、种族和死亡原因方面基本上代表了英格兰的一般人口。五个主要死因的比例与国家统计局报告的比例大致相似（均在1个百分点以内）。 结论：通过OpenSAFELY-TPP提供的数据广泛代表了英国人群。OpenSAFELY的用户必须考虑与使用TPP数据进行健康研究相关的代表性，普遍性和外部有效性问题。尽管TPP实践的覆盖范围在英格兰各地有所不同，但TPP注册患者在关键人口统计学特征方面通常代表整个英国人群。
Background: Since its inception in March 2020, data from the OpenSAFELY-TPP electronic health record platform has been used for more than 20 studies relating to the global COVID-19 emergency. OpenSAFELY-TPP data is derived from practices in England using SystmOne software, and has been used for the majority of these studies. We set out to investigate the representativeness of OpenSAFELY-TPP data by comparing it to national population estimates. Methods: With the approval of NHS England, we describe the age, sex, Index of Multiple Deprivation and ethnicity of the OpenSAFELY-TPP population compared to national estimates from the Office for National Statistics. The five leading causes of death occurring between the 1st January 2020 and the 31st December 2020 were also compared to deaths registered in England during the same period. Results: Despite regional variations, TPP is largely representative of the general population of England in terms of IMD (all within 1.1 percentage points), age, sex (within 0.1 percentage points), ethnicity and causes of death. The proportion of the five leading causes of death is broadly similar to those reported by ONS (all within 1 percentage point). Conclusions: Data made available via OpenSAFELY-TPP is broadly representative of the English population. Users of OpenSAFELY must consider the issues of representativeness, generalisability and external validity associated with using TPP data for health research. Although the coverage of TPP practices varies regionally across England, TPP registered patients are generally representative of the English population as a whole in terms of key demographic characteristics.