Resolution of a complex crisis at DNA 3' termini.
Resolution of a complex crisis at DNA 3' termini.
复制标题
解决 DNA 3 末端的复杂危机。
DOI：
10.1038/s41594-019-0215-0
复制
发表时间：
2019
影响因子：
16.8
通讯作者：
Yan,Shan
中科院分区：
文献类型：
--
作者：
Yan,Shan
在复制过程中被错误结合到DNA中的核糖核苷酸被拓扑异构酶1去除，它产生的3 '端加合物不适合DNA修复，从而损害基因组的稳定性。Li等人最近的一份报告显示，Apn2/APE2可以分解这种被阻断的3 '端，从而抑制基因组内核糖核苷酸单磷酸位点拓扑异构酶1诱导的突变。
Ribonucleotides that are misincorporated into DNA during replication are removed by topoisomerase 1, which generates 3′-terminal adducts that are not amenable to DNA repair and thus compromise genome stability. A recent report by Li et al. reveals that Apn2/APE2 resolves such blocked 3′ termini, thereby suppressing topoisomerase 1–induced mutations at ribonucleotide monophosphate sites within the genome.