An MRI study of superior temporal gyrus volume in women with schizotypal personality disorder
An MRI study of superior temporal gyrus volume in women with schizotypal personality disorder
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DOI：
10.1176/appi.ajp.160.12.2198
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发表时间：
2003-12-01
影响因子：
17.7
通讯作者：
Shenton, ME
中科院分区：
文献类型：
--
作者：
Dickey, CC;McCarley, RW;Shenton, ME
目的：异常的上级颞回在精神分裂症的研究中占有重要地位，并且在具有典型人格障碍的男性受试者中，左侧上级颞回体积较小。本文首次对一组具有典型人格障碍的女性受试者进行结构磁共振成像研究。方法：在社区招募的女性受试者的冠状面图像上绘制上级颞回（典型人格障碍组：N=21，对照组：N=29）。典型人格障碍组与对照组在左右上级颞回灰质体积上无差异。而在典型人格障碍组中，大脑半球与精神疾病家族史之间存在交互作用。此外，典型人格障碍的受试者确实表现出形式思维障碍，左侧上级颞回体积与奇怪言语之间存在负相关。这项对典型人格障碍女性受试者的研究显示，没有上级颞回体积差异，但初步研究结果表明，在典型人格障碍女性受试者中，有精神病家族史的人与没有家族史的人之间存在左右差异。这些数据也表明异常言语和左上级颞回体积之间的关联，这一发现与精神分裂症中的发现相似。因此，这项研究的结果明确强调了单独研究女性科目的重要性。
Objective: An abnormal superior temporal gyrus has figured prominently in schizophrenia research, and left superior temporal gyrus volume has been shown to be smaller in male subjects with schizotypal personality disorder. This is the first structural magnetic resonance imaging study to examine a group of female subjects with schizotypal personality disorder.Method: The superior temporal gyrus was drawn on coronal images acquired from female subjects recruited from the community (schizotypal personality disorder group: N=21, comparison group: N=29).Results: There were no gray matter volume differences in the left or right superior temporal gyrus between the subjects with schizotypal personality disorder and the comparison subjects. Within the schizotypal personality disorder group, however, there was an interaction be-tween hemisphere and family history of mental illness. Moreover, subjects with schizotypal personality disorder did demonstrate formal thought disorder and a negative correlation between left superior temporal gyrus volume and odd speech.Conclusions: This study of female subjects with schizotypal personality disorder showed no superior temporal gyrus volume differences, but preliminary findings indicate that among female subjects with schizotypal personality disorder, there is a left-right difference in those who have a family history of mental illness relative to those who do not. These data also suggest an association between abnormal speech and left superior temporal gyrus volume, a finding similar to that found in schizophrenia. Results from this study thus clearly reinforce the importance of studying female subjects separately.