Phosphatidate releases calcium from cardiac sarcoplasmic reticulum.
Phosphatidate releases calcium from cardiac sarcoplasmic reticulum.
复制标题
磷脂酸从心脏肌浆网释放钙。
DOI：
10.1016/0006-291x(80)90818-9
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发表时间：
1980
影响因子：
3.1
通讯作者：
C. Limas
中科院分区：
文献类型：
--
作者：
C. Limas
磷脂酸（PA）抑制心肌肌浆网（SR）钙的蓄积，增强SR Ca ~（++）ATP酶活性。这些影响似乎与磷脂酸诱导的SR膜的钙渗透性增加以及由此产生的钙释放有关。磷脂酸释放的钙的量取决于SR囊泡外部的钙浓度和内部的钙浓度。磷脂酸盐对肌质膜的离子转运作用为心肌细胞钙转运的调控提供了新的途径。
Phosphatidate (PA) inhibits calcium accumulation by cardiac sarcoplasmic reticulum (SR) and enhances its Ca++ATPase activity. These effects seem to be related to a phosphatidate-induced increase in the calcium permeability of the SR membrane with resultant calcium release. The amount of calcium released by phosphatidate is dependent both on the calcium concentration outside the SR vesicles and the internal calcium concentration. The ionophoric effects of phosphatidate on the sarcoplasmic membrane provide a novel pathway for controlling Ca++transport in the cardiac cell.