Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.
Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.
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Claudrum介导压力诱导的焦虑反应的双向和可逆控制。
DOI：
10.1126/sciadv.abi6375
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发表时间：
2022-03-18
期刊：
影响因子：
13.6
通讯作者：
Hashimoto H
中科院分区：
文献类型：
--
作者：
Niu M;Kasai A;Tanuma M;Seiriki K;Igarashi H;Kuwaki T;Nagayasu K;Miyaji K;Ueno H;Tanabe W;Seo K;Yokoyama R;Ohkubo J;Ago Y;Hayashida M;Inoue KI;Takada M;Yamaguchi S;Nakazawa T;Kaneko S;Okuno H;Yamanaka A;Hashimoto H
压力反应的处理涉及皮质和皮质下区域之间的全脑通讯;然而，潜在的机制仍然难以捉摸。在这里，我们表明，屏状核（CLA）是至关重要的压力诱导的焦虑相关行为的控制。使用大脑激活映射和机器学习的组合方法表明，CLA激活是暴露于急性应激源的可靠标记。在TRAP 2小鼠，允许活动依赖性的遗传标记，化学遗传激活的CLA神经元合奏标记的急性社会失败的压力（DS）引起焦虑相关的行为，而沉默的CLA合奏衰减DS诱导的焦虑相关的行为。此外，CLA从DS激活的基底外侧杏仁核神经元接收强输入，并且其电路选择性光遗传学光刺激暂时引起焦虑相关行为。最后，沉默的CLA合奏在应力暴露增加慢性DS的阻力。因此，CLA双向控制压力诱导的情绪反应，其失活可以作为增加压力恢复力的预防策略。Claudrum ensemble调节压力诱导的焦虑反应和压力恢复力。
The processing of stress responses involves brain-wide communication among cortical and subcortical regions; however, the underlying mechanisms remain elusive. Here, we show that the claustrum (CLA) is crucial for the control of stress-induced anxiety-related behaviors. A combined approach using brain activation mapping and machine learning showed that the CLA activation serves as a reliable marker of exposure to acute stressors. In TRAP2 mice, which allow activity-dependent genetic labeling, chemogenetic activation of the CLA neuronal ensemble tagged by acute social defeat stress (DS) elicited anxiety-related behaviors, whereas silencing of the CLA ensemble attenuated DS-induced anxiety-related behaviors. Moreover, the CLA received strong input from DS-activated basolateral amygdala neurons, and its circuit-selective optogenetic photostimulation temporarily elicited anxiety-related behaviors. Last, silencing of the CLA ensemble during stress exposure increased resistance to chronic DS. The CLA thus bidirectionally controls stress-induced emotional responses, and its inactivation can serve as a preventative strategy to increase stress resilience. Claustrum ensemble regulates stress-induced anxiety responses and stress resilience.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
46.9
作者：
Chen R;Gore F;Nguyen QA;Ramakrishnan C;Patel S;Kim SH;Raffiee M;Kim YS;Hsueh B;Krook-Magnusson E;Soltesz I;Deisseroth K
通讯作者：
Deisseroth K
影响因子：
3.5
作者：
Abraham A;Pedregosa F;Eickenberg M;Gervais P;Mueller A;Kossaifi J;Gramfort A;Thirion B;Varoquaux G
通讯作者：
Varoquaux G
影响因子：
3.3
作者：
Brzozka, M. M.;Unterbarnscheidt, T.;Rossner, M. J.
通讯作者：
Rossner, M. J.